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Art. -Nr.: HY-124068

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LQB-118

LQB-118 is an orally active compound derived from sandalwood. LQB-118 can inhibit the migration of glioblastoma cells and induce cell death. LQB-118 can suppress the migration and invasion of prostate cancer cells by regulating the AKT/GSK3β pathway and the expression of the MMP-9/reck genes. LQB-118 can also inhibit yeast polysaccharide-induced inflammation both in vivo and in vitro. Additionally, LQB-118 selectively induces ROS-triggered and mitochondrial-dependent apoptosis in Leishmania amazonensis. LQB-118 can be used in studies related to inflammation, infections, and cancer diseases.

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CAS. Nr.: 1219104-20-7
Formel: C₁₉H₁₂O₄
Molecular Weight:304.30

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

LQB-118 Chemical Structure

CAS. Nr.: 1219104-20-7

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle GSK-3 Isoform-spezifische Produkte anzeigen :

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	11.21 μM Compound: 5a	Growth inhibition of human A549 cells after 72 hrs by MTT assay Growth inhibition of human A549 cells after 72 hrs by MTT assay	[PMID: 20117936]
Daudi	IC₅₀	3.1 μM Compound: 5a	Growth inhibition of human Daudi cells after 24 to 72 hrs by MTT assay Growth inhibition of human Daudi cells after 24 to 72 hrs by MTT assay	[PMID: 20117936]
GLC4 cell line	IC₅₀	5.17 μM Compound: 5a	Growth inhibition of human GLC4 cells after 72 hrs by MTT assay Growth inhibition of human GLC4 cells after 72 hrs by MTT assay	[PMID: 20117936]
HCT-8	IC₅₀	2.6 μM Compound: (+/-)-1a	Antineoplastic activity against human HCT8 cells after 72 hrs by MTT assay Antineoplastic activity against human HCT8 cells after 72 hrs by MTT assay	[PMID: 22000949]
HL-60	IC₅₀	1.3 μM Compound: (+/-)-1a	Antineoplastic activity against human HL60 cells after 72 hrs by MTT assay Antineoplastic activity against human HL60 cells after 72 hrs by MTT assay	[PMID: 22000949]
HL-60	IC₅₀	2 μM Compound: 5a	Growth inhibition of human HL60 cells after 72 hrs by MTT assay Growth inhibition of human HL60 cells after 72 hrs by MTT assay	[PMID: 20117936]
J774	IC₅₀	12.7 μM Compound: (+/-)-1a	Selectivity index, ratio of IC50 for mouse J774 cells to IC50 for Leishmania amazonensis amastigotes infected in BALB/c mouse macrophages Selectivity index, ratio of IC50 for mouse J774 cells to IC50 for Leishmania amazonensis amastigotes infected in BALB/c mouse macrophages	[PMID: 22000949]
J774	IC₅₀	18.5 μM Compound: (+/-)-1a	Cytotoxicity against mouse J774 cells after 72 hrs by MTT assay Cytotoxicity against mouse J774 cells after 72 hrs by MTT assay	[PMID: 22000949]
Jurkat	IC₅₀	6.77 μM Compound: 5a	Growth inhibition of human Jurkat cells after 24 to 72 hrs by MTT assay Growth inhibition of human Jurkat cells after 24 to 72 hrs by MTT assay	[PMID: 20117936]
K562	IC₅₀	1.67 μM Compound: (+/-)-1a	Antineoplastic activity against human K562 cells after 72 hrs by MTT assay Antineoplastic activity against human K562 cells after 72 hrs by MTT assay	[PMID: 22000949]
K562	IC₅₀	1.67 μM Compound: 5a	Growth inhibition of human K562 cells after 24 to 72 hrs by MTT assay Growth inhibition of human K562 cells after 24 to 72 hrs by MTT assay	[PMID: 20117936]
K562-Lucena 1	IC₅₀	2.75 μM Compound: 5a	Growth inhibition of human K562-Lucena 1 cells after 24 to 72 hrs by MTT assay Growth inhibition of human K562-Lucena 1 cells after 24 to 72 hrs by MTT assay	[PMID: 20117936]
LNCaP	IC₅₀	1.1 μg/mL Compound: LQB-118, LQB	Cytotoxicity against human LNCAP cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human LNCAP cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24794748]
MDA-MB-435	IC₅₀	2.3 μM Compound: (+/-)-1a	Antineoplastic activity against human MDA-MB-435 cells after 72 hrs by MTT assay Antineoplastic activity against human MDA-MB-435 cells after 72 hrs by MTT assay	[PMID: 22000949]
NCI-H460	IC₅₀	12.86 μM Compound: 5a	Growth inhibition of human H460 cells after 72 hrs by MTT assay Growth inhibition of human H460 cells after 72 hrs by MTT assay	[PMID: 20117936]
PBMC	IC₅₀	>20 μM Compound: (+/-)-1a	Cytotoxicity against PHA activated human PBMC cells after 72 hrs by MTT assay Cytotoxicity against PHA activated human PBMC cells after 72 hrs by MTT assay	[PMID: 22000949]
PBMC	IC₅₀	>20 μM Compound: 5a	Growth inhibition of phytohemagglutinin-activated human PBMC cells after 24 to 72 hrs by MTT assay Growth inhibition of phytohemagglutinin-activated human PBMC cells after 24 to 72 hrs by MTT assay	[PMID: 20117936]
PC-3	IC₅₀	1.7 μg/mL Compound: LQB-118, LQB	Cytotoxicity against human PC3 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24794748]
Raji	IC₅₀	3.32 μM Compound: 5a	Growth inhibition of human Raji cells after 24 to 72 hrs by MTT assay Growth inhibition of human Raji cells after 24 to 72 hrs by MTT assay	[PMID: 20117936]
RWPE-1	IC₅₀	1.3 μg/mL Compound: LQB-118, LQB	Cytotoxicity against human RWPE1 cells assessed as inhibition of cell viability after 48 hrs by MTT assay Cytotoxicity against human RWPE1 cells assessed as inhibition of cell viability after 48 hrs by MTT assay	[PMID: 24794748]
SF-295	IC₅₀	3.6 μM Compound: (+/-)-1a	Antineoplastic activity against human SF295 cells after 72 hrs by MTT assay Antineoplastic activity against human SF295 cells after 72 hrs by MTT assay	[PMID: 22000949]

Chemical Information

CAS. Nr. 1219104-20-7
Molecular Weight 304.30
Formel C₁₉H₁₂O₄
SMILES

O=C1C2=C(C(C3=CC=CC=C31)=O)OC[C@@]4([H])[C@]2([H])OC5=CC=CC=C45
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bernardo PS, et al. LQB‑118 compound inhibits migration and induces cell death in glioblastoma cells. Oncol Rep. 2020 Jan;43(1):346-357. [Content Brief]

[2]. Martino T, et al. LQB-118 Suppresses Migration and Invasion of Prostate Cancer Cells by Modulating the Akt/GSK3β Pathway and MMP-9/Reck Gene Expression. Anticancer Res. 2023 Jan;43(1):359-367. [Content Brief]

[3]. Lima ÉA, et al. The pterocarpanquinone LQB 118 inhibits inflammation triggered by zymosan in vivo and in vitro. Int Immunopharmacol. 2020 Jun;83:106399. [Content Brief]

[4]. Ribeiro GA, et al. LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis. J Antimicrob Chemother. 2013 Apr;68(4):789-99. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
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Chemical Information
Reinheit & Dokumentation
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LQB-118

Alle GSK-3 Isoform-spezifische Produkte anzeigen

Alle MMP Isoform-spezifische Produkte anzeigen