MCI
MCI alleviates inflammation by macrophage reprogramming via targeting ROS scavenging and COX-2 downregulation. MCI inhibits COX-2 with an IC50 value of 1.23 μM. MCI has significant anti-inflammatory effects in collagen-induced arthritis (CIA) models. MCI can be used in research for rheumatoid arthritis (RA).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C45H52ClN7O13
- Molecular Weight:934.39
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
COX-2 1.23 μM (IC50) |
In Vitro
MCI (8 μM, 2 h) inhibits ROS production and COX-2 expression results in the phenotypic transition of macrophages from the M1 state to the M2 state in the LPS-stimulated RAW 264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS-stimulated RAW 264.7 cell
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Concentration:8 μM
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Incubation Time:2 h
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Result:Inhibited the level of NF-κB p65 in the nuclei.
Increased the level of CD163.
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Cell Line:LPS-stimulated RAW 264.7 cell
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Concentration:8 μM
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Incubation Time:2 h
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Result:Inhibited COX-2 and iNOS expression.
Increased arginase-1 (Arg-1) expression.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Collagen-induced arthritis (CIA) models with BALB/c mice[1]
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Dosage:1.05 mg/kg, once every three days for 18 days
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Administration:Intraarticularly injection
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Result:Reduced the average ankle thickness and clinical index.
Reduced cartilage damage and essentially intact like that of healthy mice.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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Molecular Weight 934.39
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Formel C45H52ClN7O13
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SMILES
O[C@H]1[C@H](O)[C@H](CO)OC(OCCN2C=C(C[C@H](NC(/C=C/C3=CC(O)=C(O)C=C3)=O)C(NCCCCNC(CC4=C(C)N(C(C5=CC=C(Cl)C=C5)=O)C6=CC=C(OC)C=C46)=O)=O)N=N2)[C@H]1O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MCI Related Classifications
HY-155031 Related Classifications
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