MK 436
MK 436 (MK-0436) is a metabolite with anti-trypanosomal activity that can be isolated from dog urine, particularly effective against Trypanosoma cruzi, the pathogen responsible for Chagas disease in South America.
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- CAS. Nr.: 33450-08-7
- Formel: C11H14N4O3
- Molecular Weight:250.25
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 33450-08-7
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Molecular Weight 250.25
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Formel C11H14N4O3
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SMILES
O=[N+](C1=CN=C(C2=NOC3CCCCC23)N1C)[O-]
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Synonyms
MK-0436
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Reinheit & Dokumentation
Verweise
[1]. VandenHeuvel, et al. Identification of canine urinary metabolites of the antiprotozoal agent 3a, 4, 5, 6, 7, 7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1, 2-benzisoxazole. Journal of pharmaceutical sciences 69.11 (1980): 1288-1292. [Content Brief]
[2]. Jennings, et al. Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement. Transactions of the Royal Society of Tropical Medicine and Hygiene 77.5 (1983): 693-698. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MK 436 Related Classifications
HY-117129 Related Classifications
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