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Art. -Nr.: HY-P991271

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NN-8828

(Synonyms: NNC-114-0005; NN9828; NNC01140006)

Kundenbewertung

Based on 1 Customer Validation

NN-8828 (NNC-114-0005; NN9828; NNC01140006) is a human IgG1 monoclonal antibody inhibitor targeting IL-21 that binds and neutralizes soluble IL-21 with a K_d of 0.19 pM. NN-8828 restores the balance between effector T cells and regulatory T cells, inhibits pathological antibody production, and alleviates IL-21-mediated inflammatory responses without inducing antibody-dependent cellular cytotoxicity. NN-8828 exhibits favorable biosafety. NN-8828 can be used in research related to rheumatoid arthritis, type 1 diabetes, and systemic lupus erythematosus.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 97.89%
Molecular Weight:145.12 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

NN-8828 Chemical Structure

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Preis

Verfügbarkeit

Menge

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

IL-21

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

NN-8828 neutralizes IL-21 in unspecified cell-based systems with an IC₅₀ in the sub- or low nanomolar range^[1].
NN-8828 binds to soluble IL-21 with a high affinity, having a K_d of 0.19 pM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NN-8828 (i.v.; repeat-dose; up to 39 weeks) does not cause adverse effects on the reproductive organs of cynomolgus monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

59067 [NCBI]

Accession

Q9HBE4

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Anwendung

ELISA, FACS, Functional assay

Chemical Information

Appearance Liquid
Molecular Weight 145.12 kDa
Color colorless
SMILES

[NN-8828]
Synonyms

NNC-114-0005; NN9828; NNC01140006
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Novo Nordisk A/S. A randomised, double-blind, double-dummy, placebo-controlled, parallel-group, multi-centre clinical proof-of-principle trial in adult subjects with newly diagnosed type 1 diabetes mellitus investigating the effect of NNC0114-0006 and liraglutide on preservation of beta-cell function. ClinicalTrials.gov Identifier: NCT02443155. Sponsor Trial ID: NN9828-4150. Document date: 17 September 2019.

[2]. Cañete J D, et al. Efficacy and Safety of NNC01140006, an Anti-IL-21 Monoclonal Antibody, in Patients with Active Rheumatoid Arthritis.: 947[J]. Arthritis & Rheumatology, 2014, 66: S421.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

NN-8828

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

NN-8828 Related Classifications

HY-P991271 Related Classifications