PC-046
PC-046 is a multi-target inhibitor for tyrosine receptor kinase B (TrkB), IRAK-4 and Pim-1, with IC50 of 13.4 μM, 15.4 μM and 19.1 μM, respectively. PC-046 exhibits cytotoxicity against pancreatic cancer cell BxPC3 with IC50 of 7.5-130 nM. PC-046 induces apoptosis and arrests cell cycle at G2/M phase in BxPC3. PC-046 exhibits antitumor efficacy and exhibits good pharmacokinetic characteristics in mice.
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- CAS. Nr.: 1202401-59-9
- Formel: C22H18N2O3
- Molecular Weight:358.39
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
IC50: 13.4 μM (TrkB); 15.4 μM (IRAK-4); 19.1 μM (Pim-1)
Chemical Information
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CAS. Nr. 1202401-59-9
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Molecular Weight 358.39
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Formel C22H18N2O3
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SMILES
COC1=CC(C2=C(C=CN=C2)C3=NC=C(O3)C4=CC=C(C=C4)OC)=CC=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PC-046 Related Classifications
HY-120561 Related Classifications
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