Piperin-d10
Piperin-d10 is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C17H9D10NO3
- Molecular Weight:295.40
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 94-62-2
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Molecular Weight 295.40
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Formel C17H9D10NO3
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SMILES
O=C(N1C([2H])(C([2H])(C([2H])(C([2H])(C1([2H])[2H])[2H])[2H])[2H])[2H])/C=C/C=C/C2=CC=C3OCOC3=C2
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Synonyms
Bioperine-d10; 1-Piperoylpiperidine-d10
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (169.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Paarakh PM, et al. In vitro cytotoxic and in silico activity of piperine isolated from Piper nigrum fruits Linn. In Silico Pharmacol. 2015 Dec;3(1):9. Epub 2015 Oct 29. [Content Brief]
[3]. Meghwal M,et al. Piper nigrum and piperine: an update. Phytother Res. 2013 Aug;27(8):1121-30. [Content Brief]
[4]. Li C, et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93. [Content Brief]
[5]. Zhai WJ, et al. Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice. Evid Based Complement Alternat Med. 2016;2016:8597208. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3852 mL | 16.9262 mL | 33.8524 mL | 84.6310 mL |
| 5 mM | 0.6770 mL | 3.3852 mL | 6.7705 mL | 16.9262 mL | |
| 10 mM | 0.3385 mL | 1.6926 mL | 3.3852 mL | 8.4631 mL | |
| 15 mM | 0.2257 mL | 1.1284 mL | 2.2568 mL | 5.6421 mL | |
| 20 mM | 0.1693 mL | 0.8463 mL | 1.6926 mL | 4.2316 mL | |
| 25 mM | 0.1354 mL | 0.6770 mL | 1.3541 mL | 3.3852 mL | |
| 30 mM | 0.1128 mL | 0.5642 mL | 1.1284 mL | 2.8210 mL | |
| 40 mM | 0.0846 mL | 0.4232 mL | 0.8463 mL | 2.1158 mL | |
| 50 mM | 0.0677 mL | 0.3385 mL | 0.6770 mL | 1.6926 mL | |
| 60 mM | 0.0564 mL | 0.2821 mL | 0.5642 mL | 1.4105 mL | |
| 80 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL | 1.0579 mL | |
| 100 mM | 0.0339 mL | 0.1693 mL | 0.3385 mL | 0.8463 mL |
Piperin-d10 Related Classifications
HY-W654320 Related Classifications
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