Podentamig
Based on 1 Customer Validation
Podentamig (HPN 217) is a trispecific construct with three binding domains, including an anti-CD3 domain for T cell activation, an anti-BCMA domain for binding to plasma cells, and an anti-albumin domain for half-life extension. Podentamig is applicable to research related to relapsed/refractory multiple myeloma.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.66%
- CAS. Nr.: 2851863-52-8
- Molecular Weight:53.48 kDa
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
Beschreibung
Isotype
VH-VH'-(scFv-heavy-lambda)
Species Reactivity
Human
IC50 & Target
CD3E/TNFRSF17[1]
In Vitro
Podentamig has three binding domains, including an anti-CD3 domain for T cell activation, an anti-BCMA domain for binding to plasma cells, and an anti-albumin domain for half-life extension[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
VH-VH-scFvhl
Anwendung
ELISA, FACS, Functional assay
Verified Bioactivity
-
Immobilized CD3D-CD3E Heterodimer Protein, Human (HEK293, HY-P77610) can bind Podentamig, The ED50 for this effect is 17.29 ng/mL. -
Immobilized BCMA/TNFRSF17 Protein, Human (HEK293, HY-P70827) can bind Podentamig, The ED50 for this effect is 395.8 ng/mL.
Chemical Information
-
CAS. Nr. 2851863-52-8
-
Appearance Liquid
-
Molecular Weight 53.48 kDa
-
Color Colorless to light yellow
-
SMILES
[Podentamig]
-
Synonyms
HPN 217
-
Versand
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
-
Data Sheet (272 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)