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Art. -Nr.: HY-106872

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R82913

(Synonyms: 9-Cl-TIBO)

R82913 (9-Cl-TIBO) is a potent and high selective inhibitor of HIV-1 reverse transcriptase with antiviral activity on both an RNA template (negative strand synthesis) and a DNA template (positive strand synthesis). R82913 inhibits the replication of different strains of HIV-I in CEM cells with a median IC₅₀ value of of 0.15 μM.

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CAS. Nr.: 126347-69-1
Formel: C₁₆H₂₀ClN₃S
Molecular Weight:321.87

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

R82913 Chemical Structure

CAS. Nr.: 126347-69-1

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
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Bioz

Biologische Aktivität

Beschreibung

Alle HIV Isoform-spezifische Produkte anzeigen :

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Cellular Effect

Cell Line	Type	Value	Description	References
C8166	EC₅₀	0.002 μM Compound: 1c (R 82913)	Inhibitory activity against HIV-111B in C8166 cells Inhibitory activity against HIV-111B in C8166 cells	10.1016/0960-894X(95)00203-6
C8166	CC₅₀	34 μM Compound: TIBO R-82913	Cytotoxic activity was evaluated in CD4+ lymphoblastoid cell line Cytotoxic activity was evaluated in CD4+ lymphoblastoid cell line	10.1016/0960-894X(95)00257-T
C8166	IC₅₀	0.0015 μM Compound: TIBO R-82913	Antiviral activity was evaluated by inhibition of HIV-1 replication in CD4+ lymphoblastoid cell line infected with HIV/IIIB strain Antiviral activity was evaluated by inhibition of HIV-1 replication in CD4+ lymphoblastoid cell line infected with HIV/IIIB strain	10.1016/0960-894X(95)00257-T
C8166	EC₅₀	0.002 μM Compound: R-82913	Tested against HIV-1 111B for Inhibition of viral replication by determining reduction of syncytia formation and antigen gp120 in C8166 cells, estimated by ELISA Tested against HIV-1 111B for Inhibition of viral replication by determining reduction of syncytia formation and antigen gp120 in C8166 cells, estimated by ELISA	10.1016/S0960-894X(97)00022-X
CEM-SS	CC₅₀	>10000 nM Compound: TIBO R-82913	Cytotoxicity against wild type HIV-1-IIIB strain infected CEMSS cells. Cytotoxicity against wild type HIV-1-IIIB strain infected CEMSS cells.	[PMID: 7473595]
CEM-SS	IC₅₀	>10000 nM Compound: TIBO R-82913	Inhibition of wild type HIV-1-IIIB strain replication in CEM-SS cells Inhibition of wild type HIV-1-IIIB strain replication in CEM-SS cells	[PMID: 7473595]
CEM-SS	CC₅₀	35 μM Compound: R-82913	Tested for the cytotoxicity against CEM-SS cells (determined by the inhibition of [3H]-thymidine uptake) Tested for the cytotoxicity against CEM-SS cells (determined by the inhibition of [3H]-thymidine uptake)	10.1016/S0960-894X(01)81224-5
CEM-SS	IC₅₀	0.055 μM Compound: R-82913	Tested for the inhibition of HIV-1 in CEM-SS cells measured using Syncytial assay Tested for the inhibition of HIV-1 in CEM-SS cells measured using Syncytial assay	10.1016/S0960-894X(01)81224-5
MOLT-4	IC₅₀	0.19 μM Compound: TIBO R-82913	Anti-HIV activity against HIV-1 in Molt-4 cells using 7-day infective assay Anti-HIV activity against HIV-1 in Molt-4 cells using 7-day infective assay	[PMID: 7506311]
MOLT-4	IC₅₀	19 μM Compound: TIBO R-82913	Tested for cytotoxicity in Molt-4 cells by XTT assay Tested for cytotoxicity in Molt-4 cells by XTT assay	[PMID: 7506311]
MT4	EC₅₀	33 nM Compound: 2	Effective concentration of the compound to inhibit HIV-1 replication in HIV-infected MT-4 cells Effective concentration of the compound to inhibit HIV-1 replication in HIV-infected MT-4 cells	[PMID: 15771411]
MT4	IC₅₀	0.039 μM Compound: 8b	Ability to block replication of HIV-1 virus in mock infected MT-4 cells Ability to block replication of HIV-1 virus in mock infected MT-4 cells	[PMID: 1956037]
MT4	IC₅₀	0.034 μM Compound: 1a	Concentration required for 50% protection of MT-4 cells against the cytopathic effect of HIV-1 Concentration required for 50% protection of MT-4 cells against the cytopathic effect of HIV-1	[PMID: 7877144]
MT4	IC₅₀	0.042 μM Compound: 2	Compound was tested for its anti HIV-1 activity in MT-4 cells. Compound was tested for its anti HIV-1 activity in MT-4 cells.	10.1016/S0960-894X(01)80460-1

Chemical Information

CAS. Nr. 126347-69-1
Molecular Weight 321.87
Formel C₁₆H₂₀ClN₃S
SMILES

S=C1N2C3=C(C=C(C=C3N1)Cl)CN([C@H](C2)C)C/C=C(C)\C
Synonyms

9-Cl-TIBO
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. White EL, et al. A TIBO derivative, R82913, is a potent inhibitor of HIV-1 reverse transcriptase with heteropolymer templates. Antiviral Res. 1991 Oct;16(3):257-66. [Content Brief]

[2]. Larder BA. 3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother. 1992 Dec;36(12):2664-9. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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R82913

Alle HIV Isoform-spezifische Produkte anzeigen

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

R82913 Related Classifications

HY-106872 Related Classifications