Salvicine
Salvicine is a DNA topoisomerase II inhibitor (IC50=3 μM). Salvicine increases the interaction between DNA and Topo II by interacting with the ATPase domain, inhibiting DNA degradation and ATP hydrolysis. Salvicine has anticancer activities, including inhibiting Topo II, causing DNA damage, overcoming multidrug resistance, and inhibiting tumor cell adhesion.
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- CAS. Nr.: 240423-23-8
- Formel: C20H26O4
- Molecular Weight:330.42
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Topoisomerase II 3 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
3.57 μM
Compound: 4
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In vitro cytotoxic activity against HL-60 human leukemia cell line by MTT assay (microculture terazolium colorimetric)
In vitro cytotoxic activity against HL-60 human leukemia cell line by MTT assay (microculture terazolium colorimetric)
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[PMID: 10509925] |
| P388 | IC50 |
3.49 μM
Compound: 4
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In vitro cytotoxic activity against P388 mouse leukemia cell line by MTT assay (microculture terazolium colorimetric)
In vitro cytotoxic activity against P388 mouse leukemia cell line by MTT assay (microculture terazolium colorimetric)
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[PMID: 10509925] |
| SGC-7901 | IC50 |
1.84 μM
Compound: 4
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In vitro cytotoxic activity against SGC-7901 stomach cancer solid tumor cell line by MTT assay (microculture terazolium colorimetric)
In vitro cytotoxic activity against SGC-7901 stomach cancer solid tumor cell line by MTT assay (microculture terazolium colorimetric)
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[PMID: 10509925] |
| SPC-A4 | IC50 |
2.46 μM
Compound: 4
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In vitro cytotoxic activity against SPC-A4 lung cancer solid tumor cell line by MTT assay (microculture terazolium colorimetric)
In vitro cytotoxic activity against SPC-A4 lung cancer solid tumor cell line by MTT assay (microculture terazolium colorimetric)
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[PMID: 10509925] |
Chemical Information
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CAS. Nr. 240423-23-8
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Molecular Weight 330.42
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Formel C20H26O4
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SMILES
O=C1C(C(C(C)C)=CC2=C1C(CCC(C(C)(C)O)O)=C(C)C=C2)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Dey D, et al. Investigating the anticancer potential of salvicine as a modulator of topoisomerase II and ROS signaling cascade[J]. Frontiers in oncology, 2022, 12: 899009. [Content Brief]
[2]. Meng L, et al. Salvicine, a novel DNA topoisomerase II inhibitor, exerting its effects by trapping enzyme-DNA cleavage complexes[J]. Biochemical pharmacology, 2001, 62(6): 733-741. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Salvicine Related Classifications
HY-W715630 Related Classifications
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