Sophoramine
Based on 1 publication(s) in Google Scholar
Sophoramine ((-)-Sophoramine) is a prejunctional α2-adrenoceptor inhibitor that can be found in the seeds of Sophora alopecuroides. Sophoramine inhibits prejunctional α2-adrenoceptors to facilitate norepinephrine release from adrenergic nerves. Sophoramine shows cytotoxic activity against human cancer cells, positive inotropic activity, and activity in rodent arrhythmia models. Sophoramine can be used for the research of arrhythmias.
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- Reinheit: 99%
- CAS. Nr.: 6882-66-2
- Formel: C15H20N2O
- Molecular Weight:244.33
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Sophoramine
MoreAlle Adrenergic Receptor Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
α2-adrenergic receptor |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| A549 | IC50 |
>40 μM
Compound: 4
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Antiproliferative activity against human A549 cells after 3 days by SRB assay
Antiproliferative activity against human A549 cells after 3 days by SRB assay
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[PMID: 26865176] |
| KB | IC50 |
>40 μM
Compound: 4
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Antiproliferative activity against human KB cells after 3 days by SRB assay
Antiproliferative activity against human KB cells after 3 days by SRB assay
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[PMID: 26865176] |
| MDA-MB-231 | IC50 |
>40 μM
Compound: 4
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Antiproliferative activity against human MDA-MB-231 cells after 3 days by SRB assay
Antiproliferative activity against human MDA-MB-231 cells after 3 days by SRB assay
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[PMID: 26865176] |
| MDCK | IC50 |
63.07 μM
Compound: 17
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Antiviral activity against influenza A virus (A/Hanfang/359/95(H3N2)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenic effect dosed 1 hr after viral adsorption
Antiviral activity against influenza A virus (A/Hanfang/359/95(H3N2)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenic effect dosed 1 hr after viral adsorption
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[PMID: 26132528] |
In Vitro
Sophoramine (10-4-10-3 M) produces a concentration-dependent relaxation in dog vessels and coronary[2].
Sophoramine (10-4 M) potentiates the contractile response to ransmuraf stimulation in dog mesenteric arteries and veins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 6882-66-2
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Appearance Solid
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Molecular Weight 244.33
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Formel C15H20N2O
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Color Light yellow to yellow
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SMILES
O=C1N2C([C@]3([H])[C@]4([H])[C@](CCCN4CCC3)([H])C2)=CC=C1
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Synonyms
(-)-Sophoramine
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Compound Kushen injection improves M1 macrophage polarisation and radiation-induced colitis by regulating Piezo1-mediated NF-κB/NLRP3 pathway. [Abstract]2026 May:154:158055. PMID: 41818947
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Rong ZJ, et al. A novel alkaloid from the seeds of Sophora alopecuroides L. Nat Prod Res. 2022 Apr;36(7):1864-1869. [Content Brief]
[2]. Bian K, et al. Effects of sophoramine, an alkaloid from Sophora alopecuroides on isolated dog blood vessels. J Ethnopharmacol. 1988;24(2-3):167-178. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Sophoramine Related Classifications
HY-N3198A Related Classifications
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