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Art. -Nr.: HY-145748

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SYUIQ-5

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SYUIQ-5 is a G-quadruplex ligand. SYUIQ-5 stabilizes G-quadruplex and induce senescence. SYUIQ-5 inhibits c-myc gene promoter activity. SYUIQ-5 induces cancer cells autophagy by triggering telomere damage through TRF2 delocalization from telomeres.

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Reinheit: 99.03%
CAS. Nr.: 188630-47-9
Formel: C₂₀H₂₂N₄
Molecular Weight:318.42

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

SYUIQ-5 Chemical Structure

CAS. Nr.: 188630-47-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
Bel-7402	IC₅₀	0.24 μM Compound: 1, SYUIQ-05	Cytotoxicity in human Bel7402 cells by MTT assay Cytotoxicity in human Bel7402 cells by MTT assay	[PMID: 21774525]
CNE-2	IC₅₀	0.24 μM Compound: 1, SYUIQ-05	Cytotoxicity in human CNE2 cells by MTT assay Cytotoxicity in human CNE2 cells by MTT assay	[PMID: 21774525]
HeLa	IC₅₀	0.24 μM Compound: 1, SYUIQ-05	Cytotoxicity in human HeLa cells by MTT assay Cytotoxicity in human HeLa cells by MTT assay	[PMID: 21774525]
HL-60	IC₅₀	0.24 μM Compound: 1, SYUIQ-05	Cytotoxicity in human HL60 cells by MTT assay Cytotoxicity in human HL60 cells by MTT assay	[PMID: 21774525]
K562	IC₅₀	0.24 μM Compound: 1, SYUIQ-05	Cytotoxicity in human K562 cells by MTT assay Cytotoxicity in human K562 cells by MTT assay	[PMID: 21774525]
K562	IC₅₀	2.6 μM Compound: 3	Cytotoxicity against human K562 cells assessed as cell viability by MTT assay Cytotoxicity against human K562 cells assessed as cell viability by MTT assay	[PMID: 35716866]
MCF7	IC₅₀	0.63 μM Compound: 1	Inhibition of telomerase in human MCF7 cells by cell-free telomerase repeat amplification protocol assay Inhibition of telomerase in human MCF7 cells by cell-free telomerase repeat amplification protocol assay	[PMID: 18821749]
MGC-803	IC₅₀	0.24 μM Compound: 1, SYUIQ-05	Cytotoxicity in human MGC803 cells by MTT assay Cytotoxicity in human MGC803 cells by MTT assay	[PMID: 21774525]
SUNE1	IC₅₀	0.24 μM Compound: 1, SYUIQ-05	Cytotoxicity in human SUNE1 cells by MTT assay Cytotoxicity in human SUNE1 cells by MTT assay	[PMID: 21774525]
SW-620	IC₅₀	1.7 μM Compound: 3	Cytotoxicity against human SW-620 cells assessed as cell viability by MTT assay Cytotoxicity against human SW-620 cells assessed as cell viability by MTT assay	[PMID: 35716866]

Chemical Information

CAS. Nr. 188630-47-9
Appearance Solid
Molecular Weight 318.42
Formel C₂₀H₂₂N₄
Color White to yellow
SMILES

CN(C)CCCNC(C1=C(C=CC=C1)N=C23)=C3NC4=C2C=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (314.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1405 mL

15.7025 mL

31.4051 mL

5 mM

0.6281 mL

3.1405 mL

6.2810 mL

10 mM

0.3141 mL

1.5703 mL

3.1405 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (398 KB)
- English - EN (398 KB)
- Français - FR (398 KB)
- Deutsch - DE (398 KB)
- Norwegian - NO (398 KB)
- Español - ES (398 KB)
- Swedish - SV (398 KB)
- Italian - IT (398 KB)
- Korean - KR (398 KB)
- Portuguese - PT (398 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhou WJ, et al. G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells. Mol Cancer Ther. 2009 Dec;8(12):3203-13. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1405 mL	15.7025 mL	31.4051 mL	78.5127 mL
	5 mM	0.6281 mL	3.1405 mL	6.2810 mL	15.7025 mL
	10 mM	0.3141 mL	1.5703 mL	3.1405 mL	7.8513 mL
	15 mM	0.2094 mL	1.0468 mL	2.0937 mL	5.2342 mL
	20 mM	0.1570 mL	0.7851 mL	1.5703 mL	3.9256 mL
	25 mM	0.1256 mL	0.6281 mL	1.2562 mL	3.1405 mL
	30 mM	0.1047 mL	0.5234 mL	1.0468 mL	2.6171 mL
	40 mM	0.0785 mL	0.3926 mL	0.7851 mL	1.9628 mL
	50 mM	0.0628 mL	0.3141 mL	0.6281 mL	1.5703 mL
	60 mM	0.0523 mL	0.2617 mL	0.5234 mL	1.3085 mL
	80 mM	0.0393 mL	0.1963 mL	0.3926 mL	0.9814 mL
	100 mM	0.0314 mL	0.1570 mL	0.3141 mL	0.7851 mL

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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SYUIQ-5

MCE Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

SYUIQ-5 Related Classifications

HY-145748 Related Classifications