Art. -Nr.: HY-113331

Thromboxane B2

1 Cited Publications

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Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation. Thromboxane B2 is a biological inactive product and circulating catabolite of thromboxane A2. Thromboxane B2 levels in peripheral venous blood and coronary sinus blood can be used as a diagnostic marker for angina. Thromboxane B2 level in serum is also associated with inhibition of COX-1 activity inhibition in platelets. Thromboxane B2 is a major product of prostaglandin endoperoxide metabolism. Thromboxane B2 produces dose-related decreases in airflow rate, tidal volume and dynamic lung compliance, whilst simultaneously increasing pulmonary airway resistance in dog model. Thromboxane B2 appears to be a naturally occurring bronchoactive metabolite in the bioconversion of arachidonic acid.

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Reinheit: 99.00%
CAS. Nr.: 54397-85-2
Formel: C₂₀H₃₄O₆
Molecular Weight:370.48

Speicherung:

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Thromboxane B2 Chemical Structure

CAS. Nr.: 54397-85-2

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Prostaglandin Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Thromboxane B2 (1 μM-1 mM) has an EC_15mm value of 8.7 M in isolated guinea pig tracheal contraction induction^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Thromboxane B2 (30 μg/kg, i.v., single dose) decreases the tidal volume, expiratory airflow rate and dynamic lung compliance in canine model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 54397-85-2

Appearance Solid

Molecular Weight 370.48

Formel C₂₀H₃₄O₆

Color White to off-white

SMILES

O=C(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)OC(O)C[C@@H]1O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Publications (1)

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Most Recent

ACS Pharmacol Transl Sci

Ultrasensitive Profiling of Arachidonic Acid Metabolites Based on 5‑(Diisopropylamino)amylamine Derivatization-Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry. [Abstract]

2025 Oct 4;8(11):4095-4106. PMID: 41262585

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (67.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6992 mL

13.4960 mL

26.9920 mL

5 mM

0.5398 mL

2.6992 mL

5.3984 mL

10 mM

0.2699 mL

1.3496 mL

2.6992 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=
Konzentration Konzentration

×
Volumen Volumen

×
Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

×

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

=

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

×

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:

To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO    40% PEG300    5% Tween-80    45% Saline
Solubility: ≥ 2.5 mg/mL (6.75 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

Protocol 2

Add each solvent one by one: 10% DMSO    90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.75 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

Protocol 3

Add each solvent one by one: 10% DMSO    90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.75 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg

Animal Weight (Per Animal) Animal Weight (Per Animal)
g

Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL

Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

%
+

+
%
Tween-80 + +

%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact
MedChemExpress (MCE) .

Tel: 609-228-6898
E-mail: [email protected]
Technical Support: [email protected]

Method for preparing in vivo working solution for animal experiments:
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Saline .

Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)

SDS (419 KB)

English - EN (419 KB)

Français - FR (419 KB)

Deutsch - DE (419 KB)

Norwegian - NO (419 KB)

Español - ES (419 KB)

Swedish - SV (419 KB)

Italian - IT (419 KB)

Korean - KR (419 KB)

Portuguese - PT (419 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Tada, M., et al., (1981). Elevation of thromboxane B2 levels in patients with classic and variant angina Pectoris. Circulation, 64(6), 1107–1115. [Content Brief]

[2]. Szczuko, M., et al., (2021). The Role of Thromboxane in the Course and Treatment of Ischemic Stroke: Review. International journal of molecular sciences, 22(21), 11644. [Content Brief]

[3]. Wasserman, M. A., & Griffin, R. L. (1977). Thromboxane B2--comparative bronchoactivity in experimental systems. European journal of pharmacology, 46(4), 303–313. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 2.6992 mL 13.4960 mL 26.9920 mL 67.4800 mL

5 mM 0.5398 mL 2.6992 mL 5.3984 mL 13.4960 mL

10 mM 0.2699 mL 1.3496 mL 2.6992 mL 6.7480 mL

15 mM 0.1799 mL 0.8997 mL 1.7995 mL 4.4987 mL

20 mM 0.1350 mL 0.6748 mL 1.3496 mL 3.3740 mL

25 mM 0.1080 mL 0.5398 mL 1.0797 mL 2.6992 mL

30 mM 0.0900 mL 0.4499 mL 0.8997 mL 2.2493 mL

40 mM 0.0675 mL 0.3374 mL 0.6748 mL 1.6870 mL

50 mM 0.0540 mL 0.2699 mL 0.5398 mL 1.3496 mL

60 mM 0.0450 mL 0.2249 mL 0.4499 mL 1.1247 mL

Thromboxane B2 Related Classifications

HY-113331 Related Classifications

GPCR/G Protein

Prostaglandin Receptor

Disease Areas

Inflammation or Immune System Disease Blood or Cardio-cerebrovascular Disease

Lipids

Eicosanoids Fatty Acids Lipid Metabolites

Thromboxanes Carbocyclic Fatty Acids Hydroxy Fatty Acids Unsaturated Fatty Acids

Inflammation/Immunology Cardiovascular Disease

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Keywords

Thromboxane B2
54397-85-2
Thromboxane B 2
Thromboxane B-2
Prostaglandin Receptor
Inhibitor
inhibitor
inhibit

Your Recently Viewed Products

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.6992 mL	13.4960 mL	26.9920 mL	67.4800 mL
5 mM	0.5398 mL	2.6992 mL	5.3984 mL	13.4960 mL
10 mM	0.2699 mL	1.3496 mL	2.6992 mL	6.7480 mL
15 mM	0.1799 mL	0.8997 mL	1.7995 mL	4.4987 mL
20 mM	0.1350 mL	0.6748 mL	1.3496 mL	3.3740 mL
25 mM	0.1080 mL	0.5398 mL	1.0797 mL	2.6992 mL
30 mM	0.0900 mL	0.4499 mL	0.8997 mL	2.2493 mL
40 mM	0.0675 mL	0.3374 mL	0.6748 mL	1.6870 mL
50 mM	0.0540 mL	0.2699 mL	0.5398 mL	1.3496 mL
60 mM	0.0450 mL	0.2249 mL	0.4499 mL	1.1247 mL

Thromboxane B2

1 Cited Publications

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Thromboxane B2

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Thromboxane B2

Alle Prostaglandin Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table