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Art. -Nr.: HY-158047

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UNC8900

UNC8900 is a STING PROTAC degrader with a DC₅₀ of 0.924 μM. UNC8900 binds to the Von Hippel-Lindau E3 ubiquitin ligase and recruits it to activated STING for ubiquitination and subsequent degradation. UNC8900 can be used in related research on renal cell carcinoma.
(Pink: STING ligand (HY-184545); Blue: VHL ligand (HY-138678B); Black: linker).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3094059-45-4
Formel: C₇₅H₉₉N₁₇O₁₅S
Molecular Weight:1510.76

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

UNC8900 Chemical Structure

CAS. Nr.: 3094059-45-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

UNC8900 is a STING PROTAC degrader with a DC₅₀ of 0.924 μM. UNC8900 binds to the Von Hippel-Lindau E3 ubiquitin ligase and recruits it to activated STING for ubiquitination and subsequent degradation. UNC8900 can be used in related research on renal cell carcinoma^[1]. (Pink: STING ligand (HY-184545); Blue: VHL ligand (HY-138678B); Black: linker).

Alle PROTACs Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CAKI-1	DC₅₀	0.924 μM	STING protein degradation in human Caki-1 renal cell carcinoma cells incubated for 24 hrs measured by immunoblot analysis of whole cell lysates. STING protein degradation in human Caki-1 renal cell carcinoma cells incubated for 24 hrs measured by immunoblot analysis of whole cell lysates.	37183204

In Vitro

UNC8900 (8 h) produces clear dose-dependent STING degradation in HKC-8 kidney cells after 8 hours^[1].
UNC8900 (0-31.6 μM; 24 h) potently degrades STING with a DC₅₀ of 0.924 μM and a maximum degradation level of 97.65% in Caki-1 renal cell carcinoma cells following 24 hour incubation^[1].
UNC8900 (3 μM; 0-24 h) mediates very rapid STING degradation, with measurable STING protein reduction detected as early as 2 hours post-incubation in Caki-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HKC-8 human immortalized kidney cells
Concentration:

Dose range
Incubation Time:

8 h
Result:

Induces robust, dose-dependent reduction of STING protein expression in HKC-8 cells.

Western Blot Analysis^[1]

Cell Line:

Caki-1 human renal cell carcinoma cells
Concentration:

0-31.6 μM
Incubation Time:

24 h
Result:

Degrades STING protein with a DC50 of 0.924 μM, and achieves a maximum STING degradation (Dmax) value of 97.65% after 24 hours.

Western Blot Analysis^[1]

Cell Line:

Caki-1 human renal cell carcinoma cells
Concentration:

3 μM
Incubation Time:

0, 2, 4, 8, 12, 24 h
Result:

Results in robust STING degradation occurring within 2 hours, and near-complete STING loss is observed by 8 hours.

Chemical Information

CAS. Nr. 3094059-45-4
Molecular Weight 1510.76
Formel C₇₅H₉₉N₁₇O₁₅S
SMILES

O=C(C1=CC2=C(N(C(NC(C3=CC(C)=NN3CC)=O)=N2)C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O)=NC6=C4C(OCCCN7CCOCC7)=CC(C(N)=O)=C6)C(OC)=C1)NCCOCCOCCOCCOCCC(N[C@H](C(C)(C)C)C(N8[C@@H](C[C@@H](O)C8)C(NCC9=CC=C(C%10=C(N=CS%10)C)C=C9)=O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhu Z, et al. Development of VHL-recruiting STING PROTACs that suppress innate immunity. Cellular and molecular life sciences : CMLS. 2023 May 14;80(6):149. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
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UNC8900

Alle PROTACs Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

UNC8900 Related Classifications

HY-158047 Related Classifications

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