Vitexin
Based on 14 publication(s) in Google Scholar
Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.48%
- CAS. Nr.: 3681-93-4
- Formel: C21H20O10
- Molecular Weight:432.38
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Vitexin
More- Food Chem. 2025 Dec 30:497:146992. [Abstract]
- Food Chem. 2025 Oct 15:489:144992. [Abstract]
- Food Chem. 2022 May 1:375:131872. [Abstract]
- Mol Med. 2023 Oct 27;29(1):147. [Abstract]
- J Agric Food Chem. 2026 Feb 4;74(4):4059-4071. [Abstract]
- Ind Crops Prod. 2026 May 8;246:123392.
- Ind Crops Prod. 2025 Dec 11;239:122458.
- Inflammopharmacology. 2025 Mar;33(3):1435-1454. [Abstract]
- Eur J Pharmacol. 2024 Oct 5:980:176865. [Abstract]
- Eur J Pharmacol. 2023 Jul 15:951:175787. [Abstract]
- Brain Res Bull. 2025 Jul:227:111404. [Abstract]
- Mol Biol Rep. 2026 May 11;53(1):738. [Abstract]
- Arch Physiol Biochem. 2024 Jun;130(3):275-284. [Abstract]
- Kaohsiung J Med Sci. 2025 Sep 25:e70111. [Abstract]
Customer Validation & Images
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Cell Imaging/Staining
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WB
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IHC
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RT-PCR
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Cell Proliferation/Viability Assay
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
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| BJ | EC50 |
>86.2069 μM
Compound: 1
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Antiproliferative activity against human BJ cells after 72 hrs by CelTiter-Glo assay
Antiproliferative activity against human BJ cells after 72 hrs by CelTiter-Glo assay
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[PMID: 29407975] |
| HepG2 | EC50 |
>43.29 μM
Compound: 1
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Antiproliferative activity against human HepG2 cells after 72 hrs by CelTiter-Glo assay
Antiproliferative activity against human HepG2 cells after 72 hrs by CelTiter-Glo assay
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[PMID: 29407975] |
| KOPN-8 | EC50 |
>43.29 μM
Compound: 1
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Antiproliferative activity against human KOPN8 cells after 72 hrs by CelTiter-Glo assay
Antiproliferative activity against human KOPN8 cells after 72 hrs by CelTiter-Glo assay
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[PMID: 29407975] |
| SEM | EC50 |
>43.29 μM
Compound: 1
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Antiproliferative activity against human SEM cells after 72 hrs by CelTiter-Glo assay
Antiproliferative activity against human SEM cells after 72 hrs by CelTiter-Glo assay
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[PMID: 29407975] |
| SUP-B15 | EC50 |
50.69 μM
Compound: 1
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Antiproliferative activity against human SUP-B15 cells after 72 hrs by CelTiter-Glo assay
Antiproliferative activity against human SUP-B15 cells after 72 hrs by CelTiter-Glo assay
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[PMID: 29407975] |
| THLE-2 | EC50 |
200 μM
Compound: 1
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Antiproliferative activity against human THLE2 cells after 72 hrs by CelTiter-Glo assay
Antiproliferative activity against human THLE2 cells after 72 hrs by CelTiter-Glo assay
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[PMID: 29407975] |
| UoC-B1 | EC50 |
>43.29 μM
Compound: 1
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Antiproliferative activity against human UOCB1 cells after 72 hrs by CelTiter-Glo assay
Antiproliferative activity against human UOCB1 cells after 72 hrs by CelTiter-Glo assay
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[PMID: 29407975] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3681-93-4
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Appearance Solid
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Molecular Weight 432.38
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Formel C21H20O10
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Color Light yellow to yellow
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SMILES
OC1=CC=C(C2=CC(C(C(O)=CC(O)=C3[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=C3O2)=O)C=C1
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (14)
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Journal Impact Factor
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Most Recent
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Food Chem
Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]2025 Dec 30:497:146992. PMID: 41285060 -
Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 Oct 15:489:144992. PMID: 40466530 -
Food Chem
New insights into the influences of baking and storage on the nonvolatile compounds in oolong tea: A nontargeted and targeted metabolomics study. [Abstract]2022 May 1:375:131872. PMID: 34953237 -
Mol Med
Vitexin attenuates chronic kidney disease by inhibiting renal tubular epithelial cell ferroptosis via NRF2 activation. [Abstract]2023 Oct 27;29(1):147. PMID: 37891461
Vitexin purchased from MedChemExpress. Usage Cited in: Mol Med. 2023 Oct 27;29(1):147. [Abstract]
Vitexin (30 mg/kg/day, i.g.)reduced UUO-induced renal tubular epithelial cell death, Representative images of TUNEL staining in kidney tissues.
Vitexin purchased from MedChemExpress. Usage Cited in: Mol Med. 2023 Oct 27;29(1):147. [Abstract]
The protein levels of cleaved caspase3 in the kidneys of UUO mice with or without Vitexin (30 mg/kg/day, i.g.) treatment were examined by WB.
Vitexin purchased from MedChemExpress. Usage Cited in: Mol Med. 2023 Oct 27;29(1):147. [Abstract]
Representative IHC staining of F4/80 in the kidneys of UUO mice treated with or without Vitexin (30 mg/kg/day, i.g.).
Vitexin purchased from MedChemExpress. Usage Cited in: Mol Med. 2023 Oct 27;29(1):147. [Abstract]
qRT‒PCR revealed that the mRNA levels of IL-1β, IL-6, TNF-α and MCP-1 were highly increased in the UUO group, while Vitexin (30 mg/kg/day, i.g.) treatment abrogated the increase in these inflammatory cytokines.
Vitexin purchased from MedChemExpress. Usage Cited in: Mol Med. 2023 Oct 27;29(1):147. [Abstract]
Viability of HK2 cells treated with Vitexin (25, 50, 100, 200, 400 μM).
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J Agric Food Chem
Identification and Functional Characterization of a Novel C-Glycosyltransferase from Euscaphis konishii Hayata and Its Role in C-Glycoside Biosynthesis. [Abstract]2026 Feb 4;74(4):4059-4071. PMID: 41568575 -
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Inflammopharmacology
Vitexin mitigates oxidative stress, mitochondrial damage, pyroptosis and regulates small nucleolar RNA host gene 1/DNA methyltransferase 1/microRNA-495 axis in sepsis-associated acute lung injury. [Abstract]2025 Mar;33(3):1435-1454. PMID: 39641834 -
Eur J Pharmacol
Vitexin promotes the anti-senescence effect via inhibiting JAK2/STAT3 in D-Galactose-induced progeria mice and stress-induced premature senescence. [Abstract]2024 Oct 5:980:176865. PMID: 39084453 -
Eur J Pharmacol
2023 Jul 15:951:175787. PMID: 37172926 -
Brain Res Bull
Vitexin alleviates cerebral ischemia/reperfusion injury by regulating mitophagy via the SIRT1/PINK1/Parkin pathway. [Abstract]2025 Jul:227:111404. PMID: 40441663 -
Mol Biol Rep
Vitexin inhibits renal cell carcinoma progression by targeting Galectin-1-mediated glycolytic metabolism. [Abstract]2026 May 11;53(1):738. PMID: 42113369 -
Arch Physiol Biochem
Vitexin protects against high glucose-induced endothelial cell apoptosis and oxidative stress via Wnt/β-catenin and Nrf2 signalling pathway. [Abstract]2024 Jun;130(3):275-284. PMID: 35254859 -
Kaohsiung J Med Sci
Vitexin Attenuates the Growth and Glycolysis of Acute Myeloid Leukemia Cells by Suppressing the HIF-1α-Modulated YAP Pathway Under Hypoxic Conditions. [Abstract]2025 Sep 25:e70111. PMID: 40999593
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (115.64 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
DMF : 4 mg/mL (9.25 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.81 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.81 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. He M, et al. A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia. 2016 Dec;115:74-85. [Content Brief]
[2]. Lima LKF, et al. A Brief Review on the Neuroprotective Mechanisms of Vitexin. Biomed Res Int. 2018 Dec 5;2018:4785089. [Content Brief]
[3]. Jiang J, Dai J, Cui H. Vitexin reverses the autophagy dysfunction to attenuate MCAO-induced cerebral ischemic stroke via mTOR/Ulk1 pathway. Biomed Pharmacother. 2018;99:583-590. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF / DMSO | 1 mM | 2.3128 mL | 11.5639 mL | 23.1278 mL | 57.8195 mL |
| 5 mM | 0.4626 mL | 2.3128 mL | 4.6256 mL | 11.5639 mL | |
| DMSO | 10 mM | 0.2313 mL | 1.1564 mL | 2.3128 mL | 5.7820 mL |
| 15 mM | 0.1542 mL | 0.7709 mL | 1.5419 mL | 3.8546 mL | |
| 20 mM | 0.1156 mL | 0.5782 mL | 1.1564 mL | 2.8910 mL | |
| 25 mM | 0.0925 mL | 0.4626 mL | 0.9251 mL | 2.3128 mL | |
| 30 mM | 0.0771 mL | 0.3855 mL | 0.7709 mL | 1.9273 mL | |
| 40 mM | 0.0578 mL | 0.2891 mL | 0.5782 mL | 1.4455 mL | |
| 50 mM | 0.0463 mL | 0.2313 mL | 0.4626 mL | 1.1564 mL | |
| 60 mM | 0.0385 mL | 0.1927 mL | 0.3855 mL | 0.9637 mL | |
| 80 mM | 0.0289 mL | 0.1445 mL | 0.2891 mL | 0.7227 mL | |
| 100 mM | 0.0231 mL | 0.1156 mL | 0.2313 mL | 0.5782 mL |
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