UM-203
UM-203 is a reversible covalent STING antagonist. UM-203 is effective against both mouse and human STING, and in particular, it inhibits the most common human STING R232 variant. UM-203 can inhibit STING oligomerization and reduce phosphorylation of downstream TBK1 and IRF3, thereby blocking the IRF3 and NF-κB-mediated signaling pathways and inhibiting IFNβ and IL-6 secretion. UM-203 can be used for the research of inflammation and immunology, such as systemic lupus erythematosus.
For research use only. We do not sell to patients.
- Formula: C29H24N6O2S2
- Molecular Weight:552.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TBK1 |
IL-6 |
Chemical Information
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Molecular Weight 552.67
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Formula C29H24N6O2S2
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SMILES
O=C(C1=CN=C(C2=CC=CC=C2)S1)NC3(C4=NC5=CC=CC=C5N4C)CCN(C(C6=CSC(C#C)=N6)=O)CC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UM-203 Related Classifications
HY-180120 Related Classifications
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