Bleomycin
Based on 212 publication(s) in Google Scholar
Bleomycin is a glycopeptide antibiotic. Bleomycin has potent antitumour activities against a range of lymphomas, head and neck cancers and germ-cell tumours. Bleomycin can be used for the research of cancer and chemotherapy.
For research use only. We do not sell to patients.
- CAS No.: 11056-06-7
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Publications Citing Use of MedChemExpress (MCE) Bleomycin
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- Stem Cell Res Ther. 2025 Aug 5;16(1):426. [Abstract]
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- Cell Rep. 2026 Jan 13;45(1):116854. [Abstract]
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- Cell Rep. 2024 Sep 28;43(10):114794. [Abstract]
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- J Med Chem. 2026 Apr 23;69(8):9363-9385. [Abstract]
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- J Med Chem. 2025 Apr 14. [Abstract]
- J Invest Dermatol. 2023 Jul;143(7):1289-1298.e15. [Abstract]
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- Redox Rep. 2026 Dec;31(1):2632434. [Abstract]
- Drug Deliv Transl Res. 2026 Jul;16(7):2514-2526. [Abstract]
- J Ethnopharmacol. 2026 May 23:363:121465. [Abstract]
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- Biochem Pharmacol. 2024 Nov:229:116496. [Abstract]
- Mech Ageing Dev. 2024 Apr:218:111902. [Abstract]
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- Biochem Pharmacol. 2020 Apr:174:113846. [Abstract]
- Life Sci. 2021 Jan 1:264:118664. [Abstract]
- Mol Metab. 2022 Aug:62:101524. [Abstract]
- OncoImmunology. 2020 Sep 22;9(1):1824631. [Abstract]
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- Transl Res. 2023 Jul:257:54-65. [Abstract]
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- Cells. 2022 Dec 29;12(1):145. [Abstract]
- Cells. 2021 Jan 20;10(2):202. [Abstract]
- Commun Biol. 2025 Jan 14;8(1):51. [Abstract]
- Eur J Pharmacol. 2026 May 27:178931. [Abstract]
- Respir Res. 2025 Apr 12;26(1):136. [Abstract]
- Pharmaceuticals (Basel). 2024 Oct 11;17(10):1360. [Abstract]
- Eur J Pharmacol. 2024 Oct 5:980:176843. [Abstract]
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- Clin Epigenetics. 2023 Nov 11;15(1):182. [Abstract]
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- Respir Res. 2020 Feb 19;21(1):58. [Abstract]
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- Mol Cell Toxicol. 2025 May 4.
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- J Vis Exp. 2025 May 23:(219). [Abstract]
- Gene Rep. 2023 Jul 22, 101823.
- Res Sq. 2026 Jun 16.
- SSRN. 2026 Jun 18.
- SSRN. 2026 May 16.
- bioRxiv. 2026 Apr 30.
- Res Sq. 2026 Apr 14.
- medRxiv. 2025 Nov 28.
- SSRN. 2025 Dec 12.
- Res Sq. 2025 Oct 30.
- SSRN. 2025 Oct 21.
- SSRN. 2025 Sep 3.
- Int J Exp Pathol. 2025 Sep;106(5):e70005. [Abstract]
- bioRxiv. 2025 Jul 26.
- Libyan International Journal of Natural Sciences. 2025 May 26.
- bioRxiv. 2025 May 09.
- Res Sq. 2025 May 16.
- Research Square Print. 2025 May 28.
- bioRxiv. 2025 March 19.
- bioRxiv. 2025 March 11.
- Res Sq. 2024 Oct 31.
- bioRxiv. 2024 Nov 06.
- MedComm Futur Med. 2024 Jul 19.
- Heliyon. 2024 Sep 20;10(19):e38122. [Abstract]
- bioRxiv. 2024 July 27.
- Heliyon. 2024 Jun 24;10(13):e33314. [Abstract]
- Biomed Pharmacother. 2024 Feb:171:116101. [Abstract]
- Research Square Preprint. 2023 Nov 23.
- Heliyon. 2023 Nov 20;9(12):e22461. [Abstract]
- Research Square Preprint. 2023 Aug 30.
- Research Square Preprint. 2023 Aug 4.
- Research Square Preprint. 2023 Aug 3.
- Research Square Print. November 28th, 2022.
- Biomed Pharmacother. 2022 Sep:153:113460. [Abstract]
- Universidad de las Illes Balears. Facultad de Ciencias, 2022 Feb.
- Chinese Journal of Plastic and Reconstructive Surgery. 23 December 2021.
- Oxid Med Cell Longev. 2021 Nov 1:2021:6241242. [Abstract]
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- Oxid Med Cell Longev. 2021 Jun 29:2021:9926284. [Abstract]
- Patent. US20190282565A1.
- Patent. US20190255042A1.
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All Antibiotic Isoforms
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Biological Activity
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Glycopeptide |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
53 μM
Compound: Bleomycin
|
Concentration required to reduce to 50% the number of MCF-7 cells with respect to untreated control after exposure to compound for 24 h
Concentration required to reduce to 50% the number of MCF-7 cells with respect to untreated control after exposure to compound for 24 h
|
[PMID: 12477361] |
Bleomycin (0-4 mU/mL; 1 h) induces double-strand break in V79 cells[2]. Bleomycin (0-1 mU/mL; 1 h) reduces migration of DNA from S-phase cells[2]. Bleomycin (0-3 μg/mL; 1 h) induces chromatid aberrations in G2 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57Bl/6 mice with LPB and B16F0 tumours[4]
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Dosage:1 mg and 10 μg
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Administration:Retro-orbitary sinus injection; 1 mg and 10 μg once
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Result:Decreased in the fraction of cells in mitosis in both tumours, induced cell apoptosis after the electric pulses delivery, inceased the amount of atypical cells in LPB tumours.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 11056-06-7
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SMILES
O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@H](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@]([C@H](O)C)([H])C(NCCC2=NC(C3=NC(C(N[R])=O)=CS3)=CS2)=O)=O)=O)[C@H](C4=CN=CN4)O[C@H]5[C@H]([C@H]([C@@H]([C@@H](O5)CO)O)O)O[C@]6([H])[C@H]([C@H]([C@@H]([C@H](O6)CO)O)OC(N)=O)O.NC(NCCCC[R])=N.[R]CCC[S+](C)C.[R=].[Bleomycin A2].[R=].[Bleomycin B2]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (212)
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Journal Impact Factor
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Most Recent
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Cell Res
Sensing of DNA double-strand breaks by the NHEJ system stabilizes RORγt transcriptional activity and shapes Th17 pathogenicity in autoimmunity. [Abstract]2026 Jan 7. PMID: 41495483 -
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Nat Cell Biol
2024 Sep;26(9):1545-1557. PMID: 38997456 -
Drug Resist Updat
ZBP1 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in ovarian cancer. [Abstract]2026 Jan:84:101319. PMID: 41192279 -
Nat Commun
2025 Jul 22;16(1):6734. PMID: 40695820 -
Nat Commun
A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice. [Abstract]2022 Nov 17;13(1):7028. PMID: 36396643 -
Exp Mol Med
GRIM-19-mediated induction of mitochondrial STAT3 alleviates systemic sclerosis by inhibiting fibrosis and Th2/Th17 cells. [Abstract]2024 Dec;56(12):2739-2746. PMID: 39643607 -
ACS Nano
Dissecting Discoidin Domain Receptor 2 Dynamics in Fibrosis with a Programmable Collagen-Mimetic Probe. [Abstract]2026 Jun 23;20(24):17518-17535. PMID: 42246507 -
ACS Nano
Targeted Collagen Degradation by an MRI Probe Facilitates siRNA Delivery for Sequential Theranostics in Pulmonary Fibrosis. [Abstract]2025 Apr 2. PMID: 40173291 -
J Adv Res
Plasma apolipoprotein E protein attenuates pulmonary fibrosis through LRP1 and PLAU dual receptor-mediated TGF-β/Smad inhibition. [Abstract]2025 Dec 29:S2090-1232(25)01035-5. PMID: 41475664 -
J Adv Res
Elevated lactate production exacerbates PM2.5-induced pulmonary fibrosis by stabilizing TGF-β1. [Abstract]2025 Aug 5:S2090-1232(25)00587-9. PMID: 40759348 -
J Adv Res
Kynurenine acts as a signaling molecule to attenuate pulmonary fibrosis by enhancing the AHR-PTEN axis. [Abstract]2025 May:71:521-532. PMID: 38906325 -
Redox Biol
Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis. [Abstract]2021 Oct:46:102082. PMID: 34343908 -
Mol Cell
Lactylation of XLF promotes non-homologous end-joining repair and chemoresistance in cancer. [Abstract]2025 Jul 17;85(14):2654-2672.e7. PMID: 40680721 -
J Biomed Sci
Doublecortin-like kinase 1 promotes fibroblast activation and fibrotic progression through Smad3 binding in idiopathic pulmonary fibrosis. [Abstract]2026 May 22;33(1):52. PMID: 42174588 -
MedComm (2020)
Matrix stiffness-induced α-tubulin acetylation is required for skin fibrosis formation through activation of Yes-associated protein. [Abstract]2023 Jul 12;4(4):e319. PMID: 37457658 -
Cell Rep Med
Cross-species tropism of AAV.CPP.16 in the respiratory tract and its gene therapies against pulmonary fibrosis and viral infection. [Abstract]2025 Jun 17;6(6):102144. PMID: 40409263 -
J Control Release
ROS-responsive microneedles loaded with integrin avβ6-blocking antibodies for the treatment of pulmonary fibrosis. [Abstract]2023 Aug:360:365-375. PMID: 37331606 -
Cell Death Dis
Inhibition of Rho GEFs attenuates pulmonary fibrosis through suppressing myofibroblast activation and reprogramming profibrotic macrophages. [Abstract]2025 Apr 11;16(1):278. PMID: 40216763 -
Cell Mol Biol Lett
Single-cell RNA sequencing identifies inherent abnormalities of adipose-derived stem cells from nonlesional sites of patients with localized scleroderma. [Abstract]2024 Aug 30;29(1):115. PMID: 39215271 -
Cell Death Dis
2020 Nov 12;11(11):976. PMID: 33184290 -
Cell Death Dis
Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial-mesenchymal transition and inflammation. [Abstract]2020 Nov 13;11(11):978. PMID: 33188176
Bleomycin purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Nov 13;11(11):978. [Abstract]
Bleomycin (BLM) (5 mg/kg; intratracheal instillation) significantly elevated the ratio of phosphorylated p65 to total p65 (p-p65/p65) and reduced the expression level of IκBα, indicating that NF-κB signaling pathway was activated in BLM-induced pulmonary fibrosis.
Bleomycin purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Nov 13;11(11):978. [Abstract]
Bleomycin (BLM) (5 mg/kg; intratracheal instillation) increases the expression of NLRP3 in BALB/c mice.
Bleomycin purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Nov 13;11(11):978. [Abstract]
Bleomycin (BLM) (5 mg/kg; intratracheal instillation) upregulates the mRNA levels of NLRP3, ASC, IL-1β, and IL-18 in BALB/c mice.
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Cell Death Dis
Oncogene PRR14 promotes breast cancer through activation of PI3K signal pathway and inhibition of CHEK2 pathway. [Abstract]2020 Jun 15;11(6):464. PMID: 32541902 -
Cancer Lett
N6-methyadenosine modified SUV39H2 regulates homologous recombination through epigenetic repression of DUSP6 in gastric cancer. [Abstract]2023 Apr 1:558:216092. PMID: 36806557 -
Cancer Lett
DAB2IP suppresses tumor malignancy by inhibiting GRP75-driven p53 ubiquitination in colon cancer. [Abstract]2022 Apr 28:532:215588. PMID: 35150809 -
Small
Metal-Polyphenol-Network Coated Prussian Blue Nanoparticles for Synergistic Ferroptosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent In Situ Bleomycin Toxification. [Abstract]2021 Nov;17(47):e2103919. PMID: 34623753 -
Phytomedicine
Identification of key anti-pulmonary fibrosis components in Hyssopus cuspidatus Boriss. and its mechanism exploration. [Abstract]2026 Jan:150:157676. PMID: 41389405 -
Phytomedicine
Network-guided discovery of Zeqi Decoction as a PPARγ-targeted therapy for pulmonary fibrosis. [Abstract]2026 Jan:150:157717. PMID: 41447837 -
Phytomedicine
Microbial signatures of areca nut chewing: Bridging the gap between oral dysbiosis and submucous fibrosis. [Abstract]2025 Nov:147:157227. PMID: 40934758 -
Phytomedicine
Rottlerin inhibits PKCδ to attenuate pulmonary fibrosis by suppressing NLRC4/ASC-mediated pyroptosis. [Abstract]2025 Oct:146:157154. PMID: 40819638 -
Phytomedicine
Curcumin analogue EF24 prevents alveolar epithelial cell senescence to ameliorate idiopathic pulmonary fibrosis via activation of PTEN. [Abstract]2024 Oct:133:155882. PMID: 39096545 -
Phytomedicine
Physalis Calyx seu Fructus inhibited pulmonary fibrosis through regulating Wnt/β-catenin signaling pathway. [Abstract]2024 Aug:131:155797. PMID: 38878326
Bleomycin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Aug:131:155797. [Abstract]
PCF-EtOH diminished BLM (Bleomycin sulfate)-induced increase of fibronectin, vimentin and α-SMA. All mice, except those in the control group (nebulization with saline), are nebulised with BLM/saline (1 mg/mL, 8 mL) for 30 min on days 1, 4 and 7, respectively.
Bleomycin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Aug:131:155797. [Abstract]
PCF-EtOH blocked BLM (Bleomycin sulfate)-induced upregulation of β-catenin protein. All mice, except those in the control group (nebulization with saline), are nebulised with BLM/saline (1 mg/mL, 8 mL) for 30 min on days 1, 4 and 7, respectively.
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Phytomedicine
Vincamine as an agonist of G protein-coupled receptor 40 effectively ameliorates pulmonary fibrosis in mice. [Abstract]2023 Sep:118:154919. PMID: 37392673 -
Phytomedicine
Qimai Feiluoping decoction inhibits mitochondrial complex I-mediated oxidative stress to ameliorate bleomycin-induced pulmonary fibrosis. [Abstract]2023 Apr:112:154707. PMID: 36805483 -
Adv Healthc Mater
Bioinspired Inhalable Nanoparticles Combining Chinese Herbal Tetrandrine with Pirfenidone Overcome Idiopathic Pulmonary Fibrosis via Coordinated Collagen Modulation and Fibroblast Autophagy Regulation. [Abstract]2025 Aug 21:e01916. PMID: 40842231 -
Acta Biomater
Inhaled biomimetic nanoparticles enhance pulmonary delivery of tetrandrine and pirfenidone for the treatment of idiopathic pulmonary fibrosis. [Abstract]2025 Dec 19:S1742-7061(25)00946-8. PMID: 41423167 -
J Transl Med
Vitamin D attenuates the progression of pulmonary fibrosis via inhibiting thymidine kinase 1/PFKFB3-driven glycolysis. [Abstract]2026 Apr 22;24(1):571. PMID: 42021376 -
J Transl Med
Deciphering the cellular and molecular landscape of pulmonary fibrosis through single-cell sequencing and machine learning. [Abstract]2025 Jan 2;23(1):3. PMID: 39748378 -
J Transl Med
2024 Nov 21;22(1):1051. PMID: 39574172 -
J Transl Med
2024 Apr 1;22(1):323. PMID: 38561750 -
Sci China Life Sci
Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization. [Abstract]2023 Nov;66(11):2571-2586. PMID: 37340175
Bleomycin purchased from MedChemExpress. Usage Cited in: Sci China Life Sci. 2023 Nov;66(11):2571-2586. [Abstract]
Bleomycin (1 mg/kg; single intratracheal injection). Results for time-course Western blot analysis of Plekhf1 and Arg1 (a macrophage M2 marker) and Col 1α (a fibrotic marker) expression in lung macrophages isolated from BLM-treated mice. Left panel: Representative Western blot images. Right panel: Bar graphs showing the data from three replicates.
Bleomycin purchased from MedChemExpress. Usage Cited in: Sci China Life Sci. 2023 Nov;66(11):2571-2586. [Abstract]
Bleomycin (1 mg/kg; single intratracheal injection). Representative results of coimmunostaining for Plekhf1 and F4/80 in lung sections.
Bleomycin purchased from MedChemExpress. Usage Cited in: Sci China Life Sci. 2023 Nov;66(11):2571-2586. [Abstract]
Bleomycin (1 mg/kg; single intratracheal injection). Representative results of coimmunostaining for Plekhf1 and F4/80 in BALF cells from BLM-treated mice.
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Int J Biol Macromol
2023 Jun 30:241:124476. PMID: 37076059 -
JACC Basic Transl Sci
Ubiquitin Specific Protease 9X Regulates the Activation of ARK5 and Promotes Progression of Fibrotic Remodeling. [Abstract]2025 Jul;10(7):101255. PMID: 40310323 -
-
Mol Med
2025 Jun 9;31(1):222. PMID: 40484931 -
Mol Med
LncRNA GAS5 suppresses TGF-β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoter. [Abstract]2023 Mar 14;29(1):32. PMID: 36918759 -
Antioxidants (Basel)
Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species. [Abstract]2024 May 29;13(6):667. PMID: 38929106 -
Phytother Res
Bryodulcosigenin attenuates bleomycin-induced pulmonary fibrosis via inhibiting AMPK-mediated mesenchymal epithelial transition and oxidative stress. [Abstract]2022 Oct;36(10):3911-3923. PMID: 35794782 -
Stem Cell Res Ther
A scalable platform for EPSC-Induced MSC extracellular vesicles with therapeutic potential. [Abstract]2025 Aug 5;16(1):426. PMID: 40765003 -
Stem Cell Res Ther
hAMSCs regulate EMT in the progression of experimental pulmonary fibrosis through delivering miR-181a-5p targeting TGFBR1. [Abstract]2025 Jan 5;16(1):2. PMID: 39757225 -
ACS Appl Mater Interfaces
The Clearance Effect of Tetrahedral DNA Nanostructures on Senescent Human Dermal Fibroblasts. [Abstract]2019 Jan 16;11(2):1942-1950. PMID: 30562007 -
Cell Rep
2026 Jun 25;45(7):117616. PMID: 42360879 -
Aging Cell
2026 Apr;25(4):e70462. PMID: 41910356 -
Cell Rep
Lactylation-driven nuclear RIG-I promoted by lactate transporter inhibitor suppresses DNA damage repair through inhibiting PARP1 activity. [Abstract]2026 Jan 13;45(1):116854. PMID: 41538326 -
Cell Rep
Phosphatase PHLPP1 is an alveolar-macrophage-intrinsic transcriptional checkpoint controlling pulmonary fibrosis. [Abstract]2025 Mar 12;44(3):115399. PMID: 40085643 -
Cell Rep
Mitotic ER-mitochondria contact enhances mitochondrial Ca2+ influx to promote cell division. [Abstract]2024 Sep 28;43(10):114794. PMID: 39342616 -
Chin Med
TMT proteomics analysis reveals the mechanism of bleomycin-induced pulmonary fibrosis and effects of Ginseng honeysuckle superfine powdered tea. [Abstract]2023 May 24;18(1):60. PMID: 37221600 -
J Med Chem
Discovery and Evaluation of a PROTAC Degrader Targeting SAMHD1 for the Treatment of Pulmonary Fibrosis. [Abstract]2026 Apr 23;69(8):9363-9385. PMID: 41932858 -
Anal Chem
Sequential Labeling-Assisted Precise and Multitarget Analysis of Surface Proteins on Extracellular Vesicles. [Abstract]2025 Jun 3;97(21):11073-11081. PMID: 40388194 -
J Med Chem
Identification of Nitric Oxide Donating Dasatinib Derivatives with Intraocular Pressure Lowering and Senolytic Activities. [Abstract]2025 Apr 14. PMID: 40228166 -
J Invest Dermatol
2023 Jul;143(7):1289-1298.e15. PMID: 36716923 -
Fundam Res
Pharmacological regulation of tissue fibrosis by targeting the mechanical contraction of myofibroblasts. [Abstract]2021 Dec 23;2(1):37-47. PMID: 38933917 -
Redox Rep
Prophylactic quercetin administration attenuates pulmonary fibrosis via ferroptosis-resistant priming of alveolar epithelial cells. [Abstract]2026 Dec;31(1):2632434. PMID: 41697789 -
Drug Deliv Transl Res
2026 Jul;16(7):2514-2526. PMID: 42050315 -
J Ethnopharmacol
Study on the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula by inhibiting M2 macrophage polarization and regulating TGF - β/SMAD signaling pathway. [Abstract]2026 May 23:363:121465. PMID: 41780616 -
J Ethnopharmacol
A novel polysaccharide from Qamgur (Brassica rapa L.) mitigates pulmonary fibrosis by regulating inflammatory, epithelial-mesenchymal transition, and fibrotic pathways. [Abstract]2026 Apr 6:360:121174. PMID: 41500353 -
J Ethnopharmacol
Mimosa pudica L. extract ameliorates pulmonary fibrosis via modulation of MAPK signaling pathways and FOXO3 stabilization. [Abstract]2024 Aug 10:330:118226. PMID: 38670401 -
Ecotoxicol Environ Saf
PPARγ-responsive luciferase reporter system for high-throughput screening of chemical toxins with potential pulmonary fibrosis effects. [Abstract]2025 Nov 15:307:119433. PMID: 41273832 -
Biochem Pharmacol
Targeting PBK in the fibroblast-to-myofibroblast transition: A novel therapeutic strategy for IPF. [Abstract]2025 Aug 28;242(Pt 2):117283. PMID: 40885317 -
Biochem Pharmacol
NLRP3 inflammasome activation contributes to the development of the pro-fibrotic phenotype of lung fibroblasts. [Abstract]2024 Nov:229:116496. PMID: 39159876 -
Mech Ageing Dev
Calcium transferring from ER to mitochondria via miR-129/ITPR2 axis controls cellular senescence in vitro and in vivo. [Abstract]2024 Apr:218:111902. PMID: 38218462
Bleomycin purchased from MedChemExpress. Usage Cited in: Mech Ageing Dev. 2024 Apr:218:111902. [Abstract]
miR-129 delays bleomycin-induced cellular senescence. MRC5 cells were transfected with miR-Ctrl or miR-129 and then treated with bleomycin (1 µg/ml) where indicated. Four days after transfection, the p-H2AX, ITPR2, p16, p21 and GAPDH protein levels were quantified by western blot.
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Cell Mol Life Sci
Role of transient receptor potential ankyrin 1 in idiopathic pulmonary fibrosis: modulation of M2 macrophage polarization. [Abstract]2024 Apr 18;81(1):187. PMID: 38635081
Bleomycin purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2024 Apr 18;81(1):187. [Abstract]
Bleomycin sulfate (3 mg/kg; nebulized) significantly upregulates TRPA1 protein levels in mice.
Bleomycin purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2024 Apr 18;81(1):187. [Abstract]
Bleomycin sulfate (3 mg/kg; nebulized) significantly increases TRPA1 mRNA levels in mouse lung tissues.
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Biochem Pharmacol
Nrf2 in keratinocytes protects against skin fibrosis via regulating epidermal lesion and inflammatory response. [Abstract]2020 Apr:174:113846. PMID: 32032580 -
Life Sci
Autophagy-related protein EI24 delays the development of pulmonary fibrosis by promoting autophagy. [Abstract]2021 Jan 1:264:118664. PMID: 33127511 -
Mol Metab
DNA damage to β cells in culture recapitulates features of senescent β cells that accumulate in type 1 diabetes. [Abstract]2022 Aug:62:101524. PMID: 35660116 -
OncoImmunology
Pirfenidone facilitates immune infiltration and enhances the antitumor efficacy of PD-L1 blockade in mice. [Abstract]2020 Sep 22;9(1):1824631. PMID: 33457101 -
Drug Des Devel Ther
Integrated Serum Pharmacochemistry, Network Pharmacology, and Transcriptomics Reveal the Mechanisms and Active Constituents of Qingfei Huoxue Decoction Against Bleomycin-Induced Pulmonary Fibrosis. [Abstract]2026 Apr 7:20:592770. PMID: 41970211 -
Transl Res
Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity. [Abstract]2023 Jul:257:54-65. PMID: 36754276 -
J Cell Biol
2021 Feb 1;220(2):e201911025. PMID: 33404607 -
Cells
2022 Dec 29;12(1):145. PMID: 36611939 -
Cells
Beyond the Warburg Effect: Oxidative and Glycolytic Phenotypes Coexist within the Metabolic Heterogeneity of Glioblastoma. [Abstract]2021 Jan 20;10(2):202. PMID: 33498369 -
Commun Biol
Chloride intracellular channel CLIC3 mediates fibroblast cellular senescence by interacting with ERK7. [Abstract]2025 Jan 14;8(1):51. PMID: 39809890 -
Eur J Pharmacol
2026 May 27:178931. PMID: 42203065 -
Respir Res
Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation. [Abstract]2025 Apr 12;26(1):136. PMID: 40221718 -
Pharmaceuticals (Basel)
Comparison of the Results of Modeling Pulmonary Fibrosis in Sprague Dawley Rats by Intratracheal Administration of Bleomycin in the Form of Sulfate and Chloride at a Dose of 3 mg/kg. [Abstract]2024 Oct 11;17(10):1360. PMID: 39459000 -
Eur J Pharmacol
Carbon monoxide attenuates cellular senescence-mediated pulmonary fibrosis via modulating p53/PAI-1 pathway. [Abstract]2024 Oct 5:980:176843. PMID: 39068977 -
Respir Res
MiR-125b-5p alleviates pulmonary fibrosis by inhibiting TGFβ1-mediated epithelial-mesenchymal transition via targeting BAK1. [Abstract]2024 Oct 19;25(1):382. PMID: 39427175 -
Clin Epigenetics
Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis. [Abstract]2023 Nov 11;15(1):182. PMID: 37951958 -
Respir Res
Long non-coding RNA H19 deficiency ameliorates bleomycin-induced pulmonary inflammation and fibrosis. [Abstract]2020 Nov 2;21(1):290. PMID: 33138822 -
Respir Res
Curdione ameliorates bleomycin-induced pulmonary fibrosis by repressing TGF-β-induced fibroblast to myofibroblast differentiation. [Abstract]2020 Feb 19;21(1):58. PMID: 32075634 -
Biomolecules
Notch Signaling Exacerbates Pulmonary Fibrosis by Regulating the Differentiation of CD4+ Tissue-Resident Memory T Cells. [Abstract]2026 Feb 20;16(2):328. PMID: 41750395 -
Int Immunopharmacol
BI-2536 attenuates IPF progression by inhibiting the PLK2/JNK/SP1 Signaling pathway in AT2 cells. [Abstract]2026 Jan 1;168(Pt 1):115812. PMID: 41237696 -
Int J Mol Sci
Integrating Network Pharmacology, Machine Learning, and Experimental Validation to Elucidate the Mechanism of Cardamonin in Treating Idiopathic Pulmonary Fibrosis. [Abstract]2025 Dec 25;27(1):249. PMID: 41516127 -
Int Immunopharmacol
JTE-013 reduces inflammation and improves pulmonary fibrosis by regulating the TRAF2/NF - κB/IGF-1 signaling pathway and macrophage polarization. [Abstract]2025 Dec 10:167:115727. PMID: 41172817 -
Int Immunopharmacol
Six1 promotes alveolar epithelium senescence in pulmonary fibrosis through regulating Tp53. [Abstract]2025 Sep 23:166:115554. PMID: 40991995 -
Int Immunopharmacol
CCTα and GVI iPLA2-induced aberrant phosphatidylcholine metabolism contributes to pulmonary inflammation and fibrosis. [Abstract]2025 May 27:156:114718. PMID: 40286783 -
Int Immunopharmacol
SLAMF7-expressing B cells as crucial mediators in the pathogenesis of rheumatoid arthritis-interstitial lung disease. [Abstract]2025 Apr 16:152:114392. PMID: 40056511 -
Int Immunopharmacol
CCDC59 alleviates bleomycin-induced inflammation and pulmonary fibrosis by increasing SP-B and SP-C expression in mice. [Abstract]2024 Sep 10:138:112645. PMID: 38972208 -
Int Immunopharmacol
Boningmycin induces AMPK-mediated endoplasmic reticulum-associated degradation of PD-L1 protein in human cancer cells. [Abstract]2023 Sep 15;124(Pt A):110905. PMID: 37717372 -
Int Immunopharmacol
Nesfatin-1, a novel energy-regulating peptide, alleviates pulmonary fibrosis by blocking TGF-β1/Smad pathway in an AMPKα-dependent manner. [Abstract]2023 Jul:120:110369. PMID: 37224650 -
Int Immunopharmacol
2023 Mar:116:109723. PMID: 36696855 -
Int Immunopharmacol
Nintedanib alleviates pulmonary fibrosis in vitro and in vivo by inhibiting the FAK/ERK/S100A4 signalling pathway. [Abstract]2022 Dec;113(Pt A):109409. PMID: 36461602 -
Inflammation
Toll-Like Receptor 9 Aggravates Pulmonary Fibrosis by Promoting NLRP3-Mediated Pyroptosis of Alveolar Epithelial Cells. [Abstract]2024 Oct;47(5):1744-1761. PMID: 38498270 -
Inflammation
Nintedanib Ameliorates Bleomycin-Induced Pulmonary Fibrosis, Inflammation, Apoptosis, and Oxidative Stress by Modulating PI3K/Akt/mTOR Pathway in Mice. [Abstract]2023 Aug;46(4):1531-1542. PMID: 37160579 -
Front Pharmacol
TRAF6 Suppresses the Development of Pulmonary Fibrosis by Attenuating the Activation of Fibroblasts. [Abstract]2022 May 20;13:911945. PMID: 35668944 -
Am J Respir Cell Mol Biol
2022 Feb;66(2):171-182. PMID: 34710342 -
Am J Respir Cell Mol Biol
Clioquinol Attenuates Pulmonary Fibrosis through Inactivation of Fibroblasts via Iron Chelation. [Abstract]2021 Aug;65(2):189-200. PMID: 33861690 -
Am J Respir Cell Mol Biol
Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression. [Abstract]2021 Jul;65(1):54-69. PMID: 33761308 -
Molecules
Cepharanthine Ameliorates Pulmonary Fibrosis by Inhibiting the NF-κB/NLRP3 Pathway, Fibroblast-to-Myofibroblast Transition and Inflammation. [Abstract]2023 Jan 11;28(2):753. PMID: 36677811 -
Biochim Biophys Acta Mol Basis Dis
Integrated bioinformatics and machine learning analysis identify CROT as a regulator of immunological features in idiopathic pulmonary fibrosis. [Abstract]2026 Feb;1872(2):168100. PMID: 41192648 -
Biochim Biophys Acta Mol Basis Dis
MBD2 promotes epithelial-to-mesenchymal transition (EMT) and ARDS-related pulmonary fibrosis by modulating FZD2. [Abstract]2025 Mar 12;1871(5):167798. PMID: 40081619 -
Sci Rep
Targeting colorectal cancer with pyrazolo[4,3-e][1,2,4]triazine and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides: comprehensive in vitro evaluation. [Abstract]2026 May 31. PMID: 42225755 -
Sci Rep
2026 Jan 8;16(1):4864. PMID: 41507413 -
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Biol Proced Online
Establishment of a mouse lung cancer organoid model and its applications for therapeutic screening. [Abstract]2025 Jun 16;27(1):21. PMID: 40524168 -
Sci Rep
Amifostine attenuates bleomycin-induced pulmonary fibrosis in mice through inhibition of the PI3K/Akt/mTOR signaling pathway. [Abstract]2023 Jun 28;13(1):10485. PMID: 37380638 -
Mediators Inflamm
Interleukin-19 Aggravates Pulmonary Fibrosis via Activating Fibroblast through TGF- β/Smad Pathway. [Abstract]2022 Mar 3:2022:6755407. PMID: 35281428 -
Eur J Med Res
Tetrathiomolybdate alleviates bleomycin-induced pulmonary fibrosis by reducing copper concentration and suppressing EMT. [Abstract]2025 May 19;30(1):394. PMID: 40390111 -
Cancers (Basel)
2024 Aug 21;16(16):2902. PMID: 39199672 -
J Cell Mol Med
Salvianolic Acid B Inhibited LH2 Expression to Reduce Collagen Synthesis in Pulmonary Fibrosis. [Abstract]2026 May;30(10):e71168. PMID: 42179136 -
J Cell Mol Med
Cinobufotalin Ameliorates the Development of Pulmonary Fibrosis by Suppressing the TGF-β/Smad Pathway via Regulating PI15. [Abstract]2025 Aug;29(16):e70788. PMID: 40845143 -
Cell Signal
hMOB2 deficiency impairs homologous recombination-mediated DNA repair and sensitises cancer cells to PARP inhibitors. [Abstract]2021 Nov:87:110106. PMID: 34363951 -
J Inflamm Res
Qimai Feiluoping Decoction Inhibits EndMT to Alleviate Pulmonary Fibrosis by Reducing PI3K/AKT/mTOR Pathway-Mediated the Restoration of Autophagy. [Abstract]2025 Jun 26:18:8447-8475. PMID: 40589610 -
J Inflamm Res
VISTA Deficiency Exacerbates the Development of Pulmonary Fibrosis by Promoting Th17 Differentiation. [Abstract]2024 Jun 19:17:3983-3999. PMID: 38911987 -
iScience
LRP1 activated by AT2 cell-secreted MDK inhibits fibrotic ferroptosis in idiopathic pulmonary fibrosis. [Abstract]2026 Jun 4;29(6):116212. PMID: 42305620 -
iScience
RSK1-SRF signaling axis drives fibroblast activation and pulmonary fibrosis: Genetic causality and therapeutic targeting. [Abstract]2026 Mar 30;29(5):115495. PMID: 42004028 -
Biomedicines
Secretome of hESC-Derived MSC-like Immune and Matrix Regulatory Cells Mitigate Pulmonary Fibrosis through Antioxidant and Anti-Inflammatory Effects. [Abstract]2023 Feb 5;11(2):463. PMID: 36830999 -
FASEB J
Hesperetin Alleviates Bleomycin-Induced Pulmonary Fibrosis by Modulating Cellular Senescence and Promoting Impaired Autophagy in a CISD2-Dependent Manner. [Abstract]2025 Oct 15;39(19):e71083. PMID: 41001804 -
J Pharmacol Exp Ther
Disulfiram activation of prostaglandin E2 synthesis: a novel antifibrotic mechanism in pulmonary fibrosis. [Abstract]2025 Jun;392(6):103588. PMID: 40359874 -
FEBS J
TRPM7 controls skin keratinocyte senescence by targeting intracellular calcium signaling. [Abstract]2024 Nov;291(21):4680-4695. PMID: 39185948 -
Am J Physiol Endocrinol Metab
Secreted GDF15 maintains transcriptional responses during DNA damage-mediated senescence in human beta cells. [Abstract]2024 Oct 1;327(4):E552-E562. PMID: 39196800 -
Lab Invest
2025 Aug 6;105(11):104227. PMID: 40780542 -
Front Biosci (Landmark Ed)
2023 Sep 22;28(9):209. PMID: 37796694 -
Naunyn Schmiedebergs Arch Pharmacol
Identification of potential mechanisms of Schisandrin B in the treatment of idiopathic pulmonary fibrosis by integrating network pharmacology and experimental validation. [Abstract]2025 May;398(5):5389-5403. PMID: 39549058 -
Naunyn Schmiedebergs Arch Pharmacol
Zerumbone alleviated bleomycin-induced pulmonary fibrosis in mice via SIRT1/Nrf2 pathway. [Abstract]2024 Nov;397(11):8979-8992. PMID: 38874804 -
Pathol Res Pract
Combined treatment of tacrolimus and pirfenidone effectively improves BLM-induced pulmonary fibrosis in mice by inhibiting the TGFβ1/Smad2/3 signaling. [Abstract]2025 Aug:272:156095. PMID: 40617191 -
Basic Clin Pharmacol Toxicol
7,8-Dihydroxyflavone Suppresses Experimental Pulmonary Fibrosis by Inhibiting Fibroblast-to-Myofibroblast Transformation and Epithelial-Mesenchymal Transition. [Abstract]2026 Jan;138(1):e70158. PMID: 41347324 -
Toxicol Appl Pharmacol
Mitochondrial dysfunction-associated cellular senescence is partially involved in bleomycin-induced pulmonary fibrosis in mice. [Abstract]2025 Nov:504:117524. PMID: 40840615 -
Cytokine
Role of FGF19 in regulating mitochondrial dynamics and macrophage polarization through FGFR4/AMPKα-p38/MAPK Axis in bleomycin-induced pulmonary fibrosis. [Abstract]2025 Sep:193:156978. PMID: 40550190 -
Stem Cells Int
Transcriptome and Proteome Analysis Identify Decorin as a Principal Antifibrotic Component Trapping TGF- β 1 Within Adipose-Derived Stem Cell Secretome. [Abstract]2025 May 9:2025:1416567. PMID: 40386129 -
Appl Biochem Biotechnol
CSE Induces Lung Epithelial Cell-derived Exosomal LINC01133-mediated FOXA1 Activity Through SRSF6 to Affect MRC-5 Cellular Lipid Metabolism and Autophagy. [Abstract]2026 May;198(5):3954-3974. PMID: 41793647 -
FEMS Yeast Res
Characterization of oncohistone H2B variants in Schizosaccharomyces pombe reveals a key role of H2B monoubiquitination deficiency in genomic instability by altering gene expression. [Abstract]2025 Jan 30:25:foaf027. PMID: 40402811 -
Bioorg Med Chem
Design, synthesis, and evaluation of a novel TRAIL-activated HDAC6 inhibitor for the treatment of pulmonary fibrosis. [Abstract]2024 Nov 1:113:117924. PMID: 39321740 -
BMC Pharmacol Toxicol
New tricks for old drugs- praziquantel ameliorates bleomycin-induced pulmonary fibrosis in mice. [Abstract]2024 Feb 14;25(1):18. PMID: 38355586 -
Immunobiology
HMGB1 regulates the activation of dendritic cells and CD4+ T cell responses through the modulation of autophagy in bleomycin-induced pulmonary fibrosis. [Abstract]2025 Apr 23;230(3):152906. PMID: 40311346 -
BMC Pulm Med
A selective CB2R agonist (JWH133) protects against pulmonary fibrosis through inhibiting FAK/ERK/S100A4 signaling pathways. [Abstract]2023 Nov 13;23(1):440. PMID: 37957604 -
Toxicol Lett
The MIR100HG/miR-29a-3p/Tab1 axis modulates TGF-β1-induced fibrotic changes in type II alveolar epithelial cells BLM-caused lung fibrogenesis in mice. [Abstract]2022 Jun 15:363:45-54. PMID: 35472619 -
Immunopharmacol Immunotoxicol
Atractylenolide III attenuates bleomycin-induced experimental pulmonary fibrosis and oxidative stress in rat model via Nrf2/NQO1/HO-1 pathway activation. [Abstract]2020 Oct;42(5):436-444. PMID: 32762376 -
J Gene Med
2022 Sep 30;e3451. PMID: 36181245 -
Fitoterapia
2026 May 21:192:107300. PMID: 42173173 -
Medicina (Kaunas)
Saroglitazar Ameliorates Pulmonary Fibrosis Progression in Mice by Suppressing NF-κB Activation and Attenuating Macrophage M1 Polarization. [Abstract]2025 Jun 26;61(7):1157. PMID: 40731787 -
Biomed Res Int
Protective Effects of the Wenfei Buqi Tongluo Formula on the Inflammation in Idiopathic Pulmonary Fibrosis through Inhibiting the TLR4/MyD88/NF- κ B Pathway. [Abstract]2022 Feb 7;2022:8752325. PMID: 35178456 -
Mutat Res Genet Toxicol Environ Mutagen
Role of exposure/recovery schedule in micronuclei induction by several promutagens in V79-derived cells expressing human CYP2E1 and SULT1A1. [Abstract]2016 Sep 15:808:27-37. PMID: 27637483 -
Ther Adv Chronic Dis
Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis. [Abstract]2020 Jul 30:11:2040622320940185. PMID: 32843954 -
J Mol Histol
Echinacoside ameliorates bleomycin-induced idiopathic pulmonary fibrosis by regulating macrophage polarization. [Abstract]2025 Nov 24;57(1):4. PMID: 41284091 -
Biochem Biophys Res Commun
Macrophage erythropoietin receptor signaling drives macrophage-myofibroblast transition via JAK2/STAT3 and TGF-β1/Smad3 pathways to exacerbate pulmonary fibrosis in mice. [Abstract]2026 Apr 9:808:153453. PMID: 41719615 -
Biochem Biophys Res Commun
The hematopoietic activity of EPO is unfavorable to the treatment of bleomycin-induced pulmonary fibrosis in mice. [Abstract]2024 Dec 20:739:150951. PMID: 39547119 -
Biochem Biophys Res Commun
Asiaticoside attenuates bleomycin-induced pulmonary fibrosis in A2aR-/- mice by promoting the BMP7/Smad1/5 signaling pathway. [Abstract]2020 Jun 30;527(3):662-667. PMID: 32423816 -
Biochem Cell Biol
A novel mouse model of pulmonary fibrosis: twice-repeated oropharyngeal bleomycin administration mimicking human pathology. [Abstract]2025 Jan 1:103:1-7. PMID: 39878201 -
Exp Ther Med
MicroRNA‑203a‑3p improves bleomycin and pingyangmycin sensitivity by inactivating the PI3K/AKT pathway in hemangioma. [Abstract]2024 Jan 4;27(2):80. PMID: 38274341 -
Can Respir J
Cortex Mori Radicis Mitigates Inflammation and Fibrosis in Pulmonary Fibrosis Through PI3K/AKT Pathway Suppression. [Abstract]2026;2026(1):e8459298. PMID: 42365453 -
Curr Med Sci
Therapeutic Effects of Qifangfeixian Granules on Pulmonary Fibrosis in Patients with Interstitial Lung Disease. [Abstract]2025 Sep 30. PMID: 41026340 -
In Vivo
Antagonistic Effect of Erythropoietin Receptor Signaling in Macrophages and Type II Alveolar Epithelial Cells on Pulmonary Fibrosis in Mice. [Abstract]2026 May-Jun;40(3):1517-1529. PMID: 42049419 -
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Int J Neurosci
Thymic stromal lymphopoietin modification gates chronic pain via regulation of transient receptor potential vanilloid type 1-caspase1. [Abstract]2025 Aug 7:1-9. PMID: 40758369 -
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STAR Protoc
Protocol for high-throughput viability screening and gene expression of human EndoC-βH5 β cells and pancreatic islets. [Abstract]2025 Jul 18;6(3):103955. PMID: 40682782 -
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Genes Cells
SRPKs Homolog Dsk1 Regulates Homologous Recombination Repair in Schizosaccharomyces pombe. [Abstract]2025 Jan;30(1):e13192. PMID: 39789818 -
J Vis Exp
2025 Jun 17:(220). PMID: 40622990 -
J Vis Exp
Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models. [Abstract]2025 Jun 20:(220). PMID: 40552821 -
J Vis Exp
Establishment and Validation of a Rat Model of Pulmonary Arterial Hypertension Associated with Pulmonary Fibrosis. [Abstract]2025 May 23:(219). PMID: 40489445 -
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Int J Exp Pathol
Porcine respiratory disease complex induces pulmonary fibrosis related to the aberrant sphingolipid metabolism. [Abstract]2025 Sep;106(5):e70005. PMID: 40884045 -
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Heliyon
Integrative analysis of the efficacy and pharmacological mechanism of Xuefu Zhuyu decoction in idiopathic pulmonary fibrosis via evidence-based medicine, bioinformatics, and experimental verification. [Abstract]2024 Sep 20;10(19):e38122. PMID: 39416822 -
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Heliyon
Sinomenine ameliorates bleomycin-induced pulmonary fibrosis by inhibiting the differentiation of fibroblast into myofibroblast. [Abstract]2024 Jun 24;10(13):e33314. PMID: 39050413 -
Biomed Pharmacother
Alpinetin ameliorates bleomycin-induced pulmonary fibrosis by repressing fibroblast differentiation and proliferation. [Abstract]2024 Feb:171:116101. PMID: 38228032 -
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Heliyon
Cellular and molecular mechanisms of fibrosis and resolution in bleomycin-induced pulmonary fibrosis mouse model revealed by spatial transcriptome analysis. [Abstract]2023 Nov 20;9(12):e22461. PMID: 38125541 -
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Biomed Pharmacother
Iguratimod ameliorates bleomycin-induced pulmonary fibrosis by inhibiting the EMT process and NLRP3 inflammasome activation. [Abstract]2022 Sep:153:113460. PMID: 36076570 -
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Oxid Med Cell Longev
Astragaloside IV Inhibits Bleomycin-Induced Ferroptosis in Human Umbilical Vein Endothelial Cells by Mediating LPC. [Abstract]2021 Nov 1:2021:6241242. PMID: 34760046 -
Biomed Pharmacother
Dopamine receptor agonists ameliorate bleomycin-induced pulmonary fibrosis by repressing fibroblast differentiation and proliferation. [Abstract]2021 Jul:139:111500. PMID: 33901873 -
Oxid Med Cell Longev
Gasotransmitter CO Attenuates Bleomycin-Induced Fibroblast Senescence via Induction of Stress Granule Formation. [Abstract]2021 Jun 29:2021:9926284. PMID: 34306316 -
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Purity & Documentation
References
[1]. Chen J, Stubbe J. Bleomycins: towards better therapeutics. Nat Rev Cancer. 2005;5(2):102-112. [Content Brief]
[2]. Olive PL, et al. Detection of DNA double-strand breaks through the cell cycle after exposure to X-rays, bleomycin, etoposide and 125IdUrd. Int J Radiat Biol. 1993 Oct;64(4):349-58. [Content Brief]
[3]. Allio T, Preston RJ. Increased sensitivity to chromatid aberration induction by bleomycin and neocarzinostatin results from alterations in a DNA damage response pathway. Mutat Res. 2000 Sep 20;453(1):5-15. [Content Brief]
[4]. Mekid H, et al. In vivo evolution of tumour cells after the generation of double-strand DNA breaks. Br J Cancer. 2003 Jun 2;88(11):1763-71. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bleomycin Related Classifications
HY-108345 Related Classifications
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