2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. Avotaciclib trihydrochloride

Avotaciclib trihydrochloride  (Synonyms: BEY1107 trihydrochloride)

製品番号: HY-137432A 純度: 99.60%
COA 取扱説明書 Technical Support

Avotaciclib (BEY1107) trihydrochloride is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. Avotaciclib trihydrochloride can inhibit the proliferation and induce apoptosis of tumor cells. Avotaciclib trihydrochloride can be used in the research of cancer such as pancreatic cancer and lung cancer.

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Avotaciclib trihydrochloride

Avotaciclib trihydrochloride 構造式

CAS 番号 : 1983984-01-5

容量 価格（税別） 在庫状況 数量
1 mg $155 在庫あり
5 mg $340 在庫あり
10 mg $540 在庫あり
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100 mg   お問い合わせ  

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Based on 3 publication(s) in Google Scholar

Other Forms of Avotaciclib trihydrochloride:

Avotaciclib trihydrochloride 関連抗体

Top Publications Citing Use of Products

CDK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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製品説明

Avotaciclib (BEY1107) trihydrochloride is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. Avotaciclib trihydrochloride can inhibit the proliferation and induce apoptosis of tumor cells. Avotaciclib trihydrochloride can be used in the research of cancer such as pancreatic cancer and lung cancer[1][2].

IC50 & Target[1]

CDK1

 

体外実験

Avotaciclib (0-64 μM; 48 h) trihydrochloride can inhibit cell proliferation and promote apoptosis in radiotherapy-resistant non-small cell lung cancer cell lines, and the effect is better when combined with PV-1019 (HY-125203)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Avotaciclib trihydrochloride 関連抗体

Cell Viability Assay[2]

Cell Line: Non-small cell lung cancer cells (H1437R, H1568R, H1703R and H1869R)
Concentration: 0, 0.1, 1, 2, 4, 8, 16, 32 and 64 μM
Incubation Time: 48 h
Result: Inhibited the cell viability, with EC50 values of 0.918, 0.580, 0.735 and 0.662 μM for H1437R, H1568R, H1703R and H1869R, respectively.
分子量

390.66

分子式

C13H14Cl3N7O
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=CC=C(C2=NC(N)=NC=C2)N=C1C3=NC(N)=NC=C3.[H]Cl.[H]Cl.[H]Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

DMSO : 5 mg/mL (12.80 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5598 mL 12.7989 mL 25.5977 mL
5 mM 0.5120 mL 2.5598 mL 5.1195 mL
10 mM 0.2560 mL 1.2799 mL 2.5598 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.60%

COA (248 KB) HNMR (255 KB) RP-HPLC (247 KB) MS (79 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5598 mL 12.7989 mL 25.5977 mL 63.9943 mL
5 mM 0.5120 mL 2.5598 mL 5.1195 mL 12.7989 mL
10 mM 0.2560 mL 1.2799 mL 2.5598 mL 6.3994 mL
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Avotaciclib trihydrochloride Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avotaciclib trihydrochloride1983984-01-5BEY1107 trihydrochlorideCDKApoptosisCyclin dependent kinaseorallyactivecyclindependentkinasecancerNon-small cell lung cancer cells (H1437RH1568RH1703R and H1869R)Inhibitorinhibitorinhibit

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製品名:
Avotaciclib trihydrochloride
製品番号:
HY-137432A
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