BAPTA tetracesium

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BAPTA tetracesium is a selective and cell-impermeant chelator for calcium. BAPTA tetracesium has high selectivity against magnesium and calcium. BAPTA tetracesium can also inhibit phospholipase C activity independently of their role as Ca²⁺ chelators.

For research use only. We do not sell to patients.

CAS No. : 480436-84-8

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Other In-stock Forms of BAPTA tetracesium:

BAPTA

Other Forms of BAPTA tetracesium:

BAPTA In-stock

35 Publications Citing Use of MCE BAPTA tetracesium

RT-PCR

ELISA

: BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]; BAPTA (10 μM). WB results showed that BAPTA could attenuate the Hb-induced decrease in LAMP1 and m-CTSD/pro-CTSD.

: BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]; IF results showed that BAPTA (10 μM) can partially increase the co-localization coefficients of LAMP1 and CTSD.

: BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]; BAPTA (10 μmol/L, 24 h). qRT-PCR was used to assess the mRNA level of Il6, Tnfα and Tgfβ3 in HMs.

: BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]; BAPTA (10 μmol/L, 24 h). TGF-β1 and IL-6 level in the supernatant of HMs were detected by ELISA.

: BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]; BAPTA (10 μmol/L, 24 h). The expression and location of TNF-α in HMs was assessed by confocal microscopy (c). Scale bar = 20 μm.

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Phospholipase A PLD Phospholipase C

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

PLC

In Vitro

BAPTA tetracesium is widely used as an intracellular buffer to investigate the effects caused by Ca²⁺ release from intracellular calcium stores or Ca²⁺ influx via Ca²⁺-permeable channels in the plasma membrane^[1].
BAPTA tetracesium can be introduced into cells via methods such as patch-clamp and microinjection^[1].
BAPTA tetracesium inhibits PLC activity in isolated Drosophila melanogaster photoreceptor cells with an IC₅₀ of approximately 8 mM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1004.02

Formula

C₂₂H₂₀Cs₄N₂O₁₀

CAS No.

480436-84-8

SMILES

O=C(O[Cs])CN(CC(O[Cs])=O)C1=C(OCCOC2=C(N(CC(O[Cs])=O)CC(O[Cs])=O)C=CC=C2)C=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tsien RY, et al. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 1980;19(11):2396-2404. [Content Brief]

[2]. Hardie RC. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium. 2005 Dec;38(6):547-56. [Content Brief]

[3]. Collatz MB, et al. Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses. Cell Calcium. 1997;21(6):453-459. [Content Brief]