BAX-IN-2
BAX-IN-2 is a potent and selective BAX inhibitor with an IC50 of 2.78 μM. BAX-IN-2 binds to the allosteric deep hydrophobic pocket between helices α3-α6 of the BAX protein and, by stabilizing the local conformation, inhibits BAX activation, oligomerization, and mitochondrial outer membrane permeabilization in the early apoptosis cascade. BAX-IN-2 can be used for research on acute ischemic stroke, traumatic central nervous system injury, myocardial ischemia-reperfusion, and neurodegenerative diseases.
For research use only. We do not sell to patients.
- Formula: C22H23BrN4O2
- Molecular Weight:455.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Bax 2.78 μM (IC50) |
In Vitro
BAX-IN-2 shows minimal inhibition of EGFR/HER2, and no activity is detected in a kinase panel comprising 45 kinases[1].
BAX-IN-2 (0.3-100 μM; 72 h) exhibits very low cytotoxicity in HepG2 cells and does not significantly affect cell viability, metabolic activity, or membrane integrity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 455.35
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Formula C22H23BrN4O2
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SMILES
O=C(NC1=CC2=C(C=C1)C=CN=C2NC3=CC=C(Br)C=C3)CCN4CCOCC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BAX-IN-2 Related Classifications
HY-190886 Related Classifications
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