country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-184107

Copy Link Print Information

Bcl-2-IN-25

Bcl-2-IN-25 is an orally active Bcl-2 inhibitor that induces cytotoxic activity in cancer cells. Bcl-2-IN-25 can be used in cancer-related research.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2290611-27-5
Fòrmula: C₄₇H₅₃ClN₈O₈S
Peso molecular:925.49

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Bcl-2-IN-25 Chemical Structure

No. CAS: 2290611-27-5

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Bcl-2-IN-25 is an orally active Bcl-2 inhibitor that induces cytotoxic activity in cancer cells. Bcl-2-IN-25 can be used in cancer-related research^[1].

IC₅₀ & Target

^[1]

Bcl-2

Ver todos los productos específicos de isoformas Bcl-2 Family :

In Vitro

Anti-cancer

Bcl-2-IN-25 (Example 9) inhibits viability of human small cell lung carcinoma H146, H889, and H1963 cells with IC₅₀ values of 33 nM, 0.7 nM, and 4.7 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_last	T_1/2	Bioavailability
Mice^[1]	10 mg/kg	p.o.	8168 ng·h/mL	2.3 h	64 %

In Vivo

Bcl-2-IN-25 (Example 9) (10 mg/kg; single oral gavage administration) exhibits favorable pharmacokinetic profiles in CD-1 mice, with an area under the curve AUC_LAST = 8168 h*ng/mL, an elimination half-life t_1/2 = 2.3 h, and an oral bioavailability of 64%.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

No. CAS 2290611-27-5
Peso molecular 925.49
Fòrmula C₄₇H₅₃ClN₈O₈S
SMILES

O=S(NC(C1=C(C=C(N2CCN(CC2)CC3=C(C4=CC=C(C=C4)Cl)CC(C)(CC3)C)C=C1)N5C6=C(OCCC5)NC7=NC=CC7=C6)=O)(C8=CC([N+]([O-])=O)=C(C=C8)NC[C@H]9COCCO9)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Chen Y. Condensed heterocyclic derivatives as bcl-2 inhibitors for the treatment of neoplastic diseases. WO2019040550A1. WIPO; 2019 Feb 28.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto