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Cat. No.: HY-184107

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Bcl-2-IN-25

Bcl-2-IN-25 is an orally active Bcl-2 inhibitor that induces cytotoxic activity in cancer cells. Bcl-2-IN-25 can be used in cancer-related research.

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CAS No.: 2290611-27-5
화학식: C₄₇H₅₃ClN₈O₈S
분자량:925.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Bcl-2-IN-25 Chemical Structure

CAS No.: 2290611-27-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Bcl-2-IN-25 is an orally active Bcl-2 inhibitor that induces cytotoxic activity in cancer cells. Bcl-2-IN-25 can be used in cancer-related research^[1].

IC₅₀ & Target^[1]

Bcl-2

All Bcl-2 Family Isoforms :

In Vitro

Bcl-2-IN-25 (Example 9) inhibits viability of human small cell lung carcinoma H146, H889, and H1963 cells with IC₅₀ values of 33 nM, 0.7 nM, and 4.7 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_last	T_1/2	Bioavailability
Mice^[1]	10 mg/kg	p.o.	8168 ng·h/mL	2.3 h	64 %

In Vivo

Bcl-2-IN-25 (Example 9) (10 mg/kg; single oral gavage administration) exhibits favorable pharmacokinetic profiles in CD-1 mice, with an area under the curve AUC_LAST = 8168 h*ng/mL, an elimination half-life t_1/2 = 2.3 h, and an oral bioavailability of 64%.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2290611-27-5
분자량 925.49
화학식 C₄₇H₅₃ClN₈O₈S
SMILES

O=S(NC(C1=C(C=C(N2CCN(CC2)CC3=C(C4=CC=C(C=C4)Cl)CC(C)(CC3)C)C=C1)N5C6=C(OCCC5)NC7=NC=CC7=C6)=O)(C8=CC([N+]([O-])=O)=C(C=C8)NC[C@H]9COCCO9)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Chen Y. Condensed heterocyclic derivatives as bcl-2 inhibitors for the treatment of neoplastic diseases. WO2019040550A1. WIPO; 2019 Feb 28.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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Bcl-2-IN-25

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bcl-2-IN-25 Related Classifications

HY-184107 Related Classifications