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Cat. No.: HY-136994

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Sphingolactone-24

(Synonyms: Sph-24)

Sphingolactone-24 (Sph-24) is a selective and irreversible neutral sphingomyelinase (nSMase) inhibitor. Sphingolactone-24 has the potential for the research of acute lung injury.

For research use only. We do not sell to patients.

CAS No.: 881177-99-7
Formula: C₁₈H₂₉NO₄
Molecular Weight:323.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Sphingolactone-24 Chemical Structure

CAS No.: 881177-99-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Sphingolactone-24 (Sph-24) is a selective and irreversible neutral sphingomyelinase (nSMase) inhibitor. Sphingolactone-24 has the potential for the research of acute lung injury^[1].

All Phospholipase Isoforms :

In Vitro

Sphingolactone-24 (50 µM; 30 min+24 h) inhibits LPS-induced p38 MAPK phosphorylation and antagonized the antiapoptotic effect LPS (HY-D1056)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

human neutrophils
Concentration:

50 µM
Incubation Time:

30 min +24 h (30 min before LPS (500 ng/ml) treatment)
Result:

Inhibited LPS-induced p38 MAPK phosphorylation and antagonized the antiapoptotic effect of LPS.

In Vivo

Sphingolactone-24 (1 mg/kg; i.p.; 3 and 9 h thereafter LPS) reduces the severity of LPS-induced ALI and increases the survival rate of LPS-induced lung injury mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C3H/HeN breeder mice (LPS 10 mg/kg; intranasal instillation)^[1]
Dosage:

1 mg/kg
Administration:

I.p.; 3 and 9 h thereafter LPS
Result:

Improved survival and reduced the severity of LPS-induced acute lung injury (ALI).

Chemical Information

CAS No. 881177-99-7
Molecular Weight 323.43
Formula C₁₈H₂₉NO₄
SMILES

C/C=C/C=C/C(N[C@H]([C@@]1([H])CC(C(O1)=O)CCCCCC)CO)=O
Synonyms

Sph-24
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lin WC, et al. Inhibition of neutrophil apoptosis via sphingolipid signaling in acute lung injury. J Pharmacol Exp Ther. 2011 Oct;339(1):45-53. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Sphingolactone-24

All Phospholipase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Sphingolactone-24 Related Classifications

HY-136994 Related Classifications