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Cat. No.: HY-N19903

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Verticilatin

Verticilatin is a prenylated diaryl ether derived from phytopathogenic fungi, acting as an antibacterial agent and biofilm inhibitor. Verticilatin exhibits no direct growth inhibitory activity against Gram-negative bacteria. Verticilatin effectively inhibits the growth of Gram-positive strains, including methicillin-sensitive/resistant Staphylococcus aureus and Enterococcus faecalis, and reduces the biofilm-forming ability of Gram-negative Stenotrophomonas maltophilia. Verticilatin can be used for infections caused by the aforementioned Gram-positive bacteria and biofilm infections caused by Stenotrophomonas maltophilia.

For research use only. We do not sell to patients.

CAS No.: 2243140-21-6
Formula: C₁₉H₂₂O₃
Molecular Weight:298.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Verticilatin Chemical Structure

CAS No.: 2243140-21-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Antibiotic Isoforms :

In Vitro

Verticilatin (4 mg/L) does not inhibit growth of Gram-negative bacteria, reduces biofilm formation in two Stenotrophomonas maltophilia strains by up to 63%, and potently inhibits growth of Gram-positive MSSA, MRSA, and Enterococcus faecalis strains with an MIC of 4 mg/L^[1].
Verticilatin (2a) (4 mg/L; 24 h) potently inhibits the growth of MSSA ATCC25923, MRSA GK2235, MRSA USA300, and Enterococcus faecalis ATCC29212 with an MIC of 4 mg/L for all tested strains^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 2243140-21-6
Molecular Weight 298.38
Formula C₁₉H₂₂O₃
SMILES

OC1=CC(C)=CC(OC2=CC(C)=C(C/C=C(C)\C)C(O)=C2)=C1
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Staphylococcus aureus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Signal Pathway Related Histomorphology

Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Gram Staining of Tissue Sections
Gram staining of tissue sections is a histochemical technique used to differentiate Gram-positive and Gram-negative bacteria within histological specimens based on differences in bacterial cell wall structure and dye retention, adapted from classical bacteriological Gram staining into tissue-compatible “histological Gram stain” variants. In tissue applications, modifications of the Brown-Hopps and Brown-Brenn methods are commonly used to improve differentiation of microorganisms embedded within host connective tissue and to reduce overstaining or loss of Gram-negative signal, which are known limitations of earlier approaches. The principle relies on crystal violet-iodine complex retention in Gram-positive organisms and subsequent decolorization and counterstaining steps that allow contrast visualization of Gram-negative organisms against tissue background.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Boehlich G J. Synthesis of Diorcinols and C-acyl glycosidic compounds[D]. Staats-und Universitätsbibliothek Hamburg Carl von Ossietzky, 2022.

[2]. Boehlich GJ, et al. Total Synthesis of Anti-MRSA Active Diorcinols and Analogues. Chemistry (Weinheim an der Bergstrasse, Germany). 2020 Aug 06;26(44):9846-9850. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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