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1400W

(Synonyms: W1400)
29 Cited Publications
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Based on 29 publication(s) in Google Scholar

1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation.

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  • Pureté: 98.49%
  • CAS No.: 180001-34-7
  • Formule: C10H15N3
  • Masse moléculaire:177.25
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • 1400W Chemical Structure
    1400W Chemical Structure
  • Experimental Validation Results for 1400W
  • Experimental Validation Results for 1400W
  • Experimental Validation Results for 1400W
  • Experimental Validation Results for 1400W
  • Experimental Validation Results for 1400W
CAS No.: 180001-34-7
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  • 1400W Chemical Structure
    1400W Chemical Structure
    1/16
  • 1/16

    1400W purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Jul 3;10(1):209. [Abstract]

    Customer Validation
     1400W dihydrochloride inhibited PA-induced LDH release in Vγ9Vδ2-T cells.

  • 1/16

    1400W purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Jul 3;10(1):209. [Abstract]

    Customer Validation
     1400W dihydrochloride treatment effectively suppressed the induction of GSDMD cleavage and caspase 1 activation of Vγ9Vδ2-T cells following rhIFNγ stimulation under BSA or OA conditions.

  • 1/16

    1400W purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Jan 7;37(1):291-304.e9. [Abstract]

    Customer Validation
     Effects of NOS inhibitors on phagocytosis efficiency in M0 and M1 BMDMs. The results showed that treatment with the NOS inhibitor 1400W dihydrochloride suppressed the phagocytic efficiency of activated M1 BMDMs, implying that NOS‑mediated arginine metabolism was crucial for macrophage phagocytosis.

  • 1/16

    1400W purchased from MedChemExpress. Usage Cited in: Mol Cell. 2020 Jan 2;77(1):95-107.e5. [Abstract]

    Customer Validation
     HT29 cells with depleted PTPS and reconstituted expression of rPTPS R25Q were cultured for 12 h under hypoxia and were treated with the indicated concentration of exogenous BH4 in the presence or absence of 1400W Dihydrochloride (100 μM). The S-nitrosylation detection assay was performed. Addition of a high dosage of exogenous BH4 led to an increased LTBP1 S-nitrosylation under hypoxia in HT29 cells with expression of PTPS R25Q. The effects of exogenous BH4 found here were abolished when cells were treated with the iNOS inhibitor 1400W Dihydrochloride.

  • 1/16

    1400W purchased from MedChemExpress. Usage Cited in: Mol Cell. 2020 Jan 2;77(1):95-107.e5. [Abstract]

    Customer Validation
     HT29 cells with depleted PTPS and reconstituted expression of rPTPS R25Q were cultured for 12 h under hypoxia and were added with indicated concentrations of exogenous BH4 in the presence or absence of 1400W Dihydrochloride (100 mM). Cells were treated with cycloheximide (CHX; 30 mg/mL) for the indicated length of time at 6 h under hypoxia treatment. Immunoblotting and relative intensities of LTBP1 to beta-actin were analyzed. Addition of a high dosage of exogenous BH4 led to decreased LTBP1 stability and increased LTBP1 ubiquitination. The effects of exogenous BH4 were abolished when cells were treated with the iNOS inhibitor 1400W Dihydrochloride.

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