17(S)-HETE
17S-HETE is arachidonic acid metabolite through cytochrome P-450 pathways. 17S-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy.
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- CAS No.: 183509-25-3
- Formule: C20H32O3
- Masse moléculaire:320.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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HY-116444
16(S)-HETENeutrophil activity Inhibitor -
HY-120894
16(R)-HETEvasodilator -
HY-120954
14,15-EE-5(Z)-E14,15-EET structural analogue -
HY-118332
19(R)-HETEVasodilator -
HY-165067
14,15-EE-8(Z)-EVasodilator Agonist -
HY-165078
(±)11(12)-EpETEComponent of PUFAs -
HY-N12970
14S(15R)-EET -
HY-Z8643
HCTZ-CH2-HCTZHCTZ Isomer
Activité biologique
Description
IC50 & Target
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CYP1B1 |
In Vitro
17S-HETE (5-20 μM) promotes the development of cardiac hypertrophy in human, through increasing CY1B1 at activity and protein levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:AC16
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Concentration:5-20 µM
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Incubation Time:24 h
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Result:Increased β/α-MHC ratio, mRNA levels of β-MHC, ANP and CYP1B1, cell surface area by 124%, 250%, 120%, 210% and 117%, respectively.
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Cell Line:AC16
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Concentration:20 µM
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Incubation Time:24 h
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Result:Increased levels of CYP1B1.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand White rabbit[2]
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Dosage:1-20 μg
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Administration:injection into artery
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Result:Inhibited more than 70% ATPase activity at the concentration of 2 μM.
Chemical Information
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CAS No. 183509-25-3
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Masse moléculaire 320.47
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Formule C20H32O3
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SMILES
OC(CCC/C=C\C/C=C\C/C=C\C/C=C\C[C@@H](O)CCC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Isse FA, et al., 17-(R/S)-hydroxyeicosatetraenoic acid (HETE) induces cardiac hypertrophy through the CYP1B1 in enantioselective manners. Prostaglandins Other Lipid Mediat. 2023 Oct;168:106749. [Content Brief]
[2]. Carroll MA, e al., Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol. 1996 Oct;271(4 Pt 2):R863-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
17(S)-HETE Related Classifications
HY-116050 Related Classifications
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