Copy Link Print Information

A 83-01

134 Cited Publications
Avis client

Based on 134 publication(s) in Google Scholar

A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

  • Pureté: 99.41%
  • CAS No.: 909910-43-6
  • Formule: C25H19N5S
  • Masse moléculaire:421.52
  • Stockage:

    -20°C, protect from light, stored under nitrogen

    * The compound is unstable in solutions, freshly prepared is recommended.

  • A 83-01 Chemical Structure
  • Experimental Validation Results for A 83-01
  • Experimental Validation Results for A 83-01
  • Experimental Validation Results for A 83-01
  • Experimental Validation Results for A 83-01
  • Experimental Validation Results for A 83-01
  • A 83-01 Chemical Structure
    A 83-01 Chemical Structure
  • Experimental Validation Results for A 83-01
  • Experimental Validation Results for A 83-01
  • Experimental Validation Results for A 83-01
  • Experimental Validation Results for A 83-01
  • Experimental Validation Results for A 83-01
CAS No.: 909910-43-6
Size
Prix
Stock
Quantité
Amount: USD 0.00
Please select quantity
or
or

* Veuillez sélectionner la quantité avant d'ajouter des articles.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of A 83-01:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
  • Activité biologique
  • Chemical Information
  • Solvant et solubilité
  • Protocole
  • Pureté et documentation
  • Références
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) A 83-01

More
Customer Validation & Images
IFWBRT-PCRCell Proliferation/Viability Assay
  • RT-PCR
  • IF
  • Cell Proliferation/Viability Assay
  • IF
  • WB

Voir tous les produits spécifiques à Isoform TGF-β Receptor

More
Keywords
100 mg

Obtenir un devis En stock

Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Enregistrer
Sign in to MedChemExpress
Enregistrer un nouveau compte

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • A 83-01 Chemical Structure
    A 83-01 Chemical Structure
    1/16
  • 1/16

    A 83-01 purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 May 2;85(9):1628-1643. [Abstract]

    Customer Validation
     A83-01 (10 μM; 12 h) suppresses the expression of XYLT1 in bone-metastatic A549 cells.

  • 1/16

    A 83-01 purchased from MedChemExpress. Usage Cited in: Nat Genet. 2024 Feb;56(2):294-305. [Abstract]

    Customer Validation
     Trophoblast organoids constructed from hTSCs-BL. Trophoblast markers: CDH1 and hCG. Briefly, hTSCs were cultured in hTSCs medium (DMEM/F12 supplemented with 0.1 mM 2-mercaptoethanol, 0.2% FBS, 0.5% Penicillin–Streptomycin, 0.3% BSA, 1% ITS-X supplement, 1.5 μg/ml L-ascorbicacid, 50 ng/mL Epidermal Growth Factor (EGF)(MedChemExpress), 2 μM CHIR99021 (MedChemExpress), 0.5 μM A83-01 (MedChemExpress), 1 μM SB431542 (MedChemExpress), 0.8 mM Valproic acid and 5 μM Y27632 (MedChemExpress).

  • 1/16

    A 83-01 purchased from MedChemExpress. Usage Cited in: Genome Med. 2024 Apr 24;16(1):60. [Abstract]

    Customer Validation
     Cell viability assessment in the AtT20 cell line treated with Activin A (10 ng/ml) in the presence or absence of SB-505124 (1 μM), A 83–01 (1 μM; 24-96 h), or follistatin (100 ng/ml). K Cell viability analysis in AtT20 cell line with shEV-GFP or shAcvr1b treated with Activin A (10 ng/ml).

  • 1/16

    A 83-01 purchased from MedChemExpress. Usage Cited in: FASEB J. 2020 Aug;34(8):11185-11199. [Abstract]

    Customer Validation
     Changes in the expression of E-Cadherin (green) and Vimentin (red) are detected by immunofluorescence. TGF-β1-induced changes in the expression of protein markers during EMT were blocked after A83-01 treatment.

  • 1/16

    A 83-01 purchased from MedChemExpress. Usage Cited in: Gynecol Oncol. 2019 Jun;153(3):639-650. [Abstract]

    Customer Validation
     Analysis of E-cadherin, N-cadherin,MMP-2 and pSmad2 in SK-OV-3 and OVCAR-3 cells treated with platelets, A83-01 or their combination at protein levels (n=3). GAPDH is used as loading control.

  • A 83-01