Heparin
Based on 10 publication(s) in Google Scholar
Heparin is a highly sulfated glycosaminoglycan,that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. Heparin significantly inhibits exosome-cell interactions.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 9005-49-6
-
Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Heparin
More- Nat Immunol. 2025 Oct;26(10):1660-1672. [Abstract]
- Nat Commun. 2026 Feb 28;17(1):3324. [Abstract]
- Redox Biol. 2025 Sep 22:87:103877. [Abstract]
- Phytomedicine. 2026 Jul:156:158184. [Abstract]
- Mol Med. 2025 Aug 16;31(1):278. [Abstract]
- Pharmaceutics. 2025 Nov 27;17(12):1524. [Abstract]
- EMBO Rep. 2025 Sep 15. [Abstract]
- J Thromb Haemost. 2026 Sep;24(9):3213-3223.
- iScience. 2025 Oct 6;28(11):113718. [Abstract]
- Tissue Cell. 2025 Dec:97:103094. [Abstract]
Customer Validation & Images
-
ELISA
-
ELISA
-
Bio/Physico-chemical Assay
-
Cell Imaging/Staining
-
Cell Imaging/Staining
Voir tous les produits spécifiques à Isoform Endogenous Metabolite
More
Activité biologique
|
Human Endogenous Metabolite |
Heparin (6 days) reduces the cytopathogenicity of HIV for MT-4 cells, with an IC50 of 7.5 μg/mL[2].
Heparin (0.5 U/mL, 48 h) inhibits HGF-induced trophoblast invasion in the SGHPL-4 cell line[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 9005-49-6
-
Appearance Solid
-
Color White to off-white
-
SMILES
O[C@H]1[C@H](O[C@H]2[C@H](OS(O)(=O)=O)[C@@H](O)[C@H](OC)[C@H](C(O)=O)O2)[C@@H](COS(O)(=O)=O)O[C@H](OC)[C@@H]1NS(O)(=O)=O.[n]
-
Structure Classification
-
Initial Source
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (10)
-
Journal Impact Factor
-
Most Recent
-
Nat Immunol
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response. [Abstract]2025 Oct;26(10):1660-1672. PMID: 40954252 -
Nat Commun
Targeting leucine-rich repeat kinase 2 overcomes resistance to oncolytic herpes simplex virus-based therapies in glioblastoma. [Abstract]2026 Feb 28;17(1):3324. PMID: 41764166 -
Redox Biol
Synthetic anticoagulant octaparin targets mitochondrial cardiolipin-GSDMD axis to rescue redox homeostasis in sepsis. [Abstract]2025 Sep 22:87:103877. PMID: 40992080
Heparin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep 22:87:103877. [Abstract]
ELISA analysis of TNF-α in culture supernatants from BMDMs stimulated with LPS (1 μg/mL) in the presence or absence of octaparin (5 μg/mL), heparin (5 μg/mL), enoxaparin (5 μg/mL) and fondaparinux (5 μg/mL) for 24 h.
Heparin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep 22:87:103877. [Abstract]
ELISA analysis of IL-6 in culture supernatants from BMDMs stimulated with LPS (1 μg/mL) in the presence or absence of octaparin (5 μg/mL), heparin (5 μg/mL), enoxaparin (5 μg/mL) and fondaparinux (5 μg/mL) for 24 h.
Heparin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep 22:87:103877. [Abstract]
Relative fluorescence intensity of TMRM in BMDMs treated with LPS (1 μg/mL) for 24 h in the presence or absence of octaparin (5 μg/mL), heparin (5 μg/mL), enoxaparin (5 μg/mL) and fondaparinux (5 μg/mL).
Heparin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep 22:87:103877. [Abstract]
Relative fluorescence intensity of MitoSOX in BMDMs treated with LPS (1 μg/mL) for 24 h in the presence or absence of octaparin (5 μg/mL), heparin (5 μg/mL), enoxaparin (5 μg/mL) and fondaparinux (5 μg/mL).
Heparin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep 22:87:103877. [Abstract]
Relative fluorescence intensity of H2DCFDA in BMDMs treated with LPS (1 μg/mL) for 24 h in the presence or absence of octaparin (5 μg/mL), heparin (5 μg/mL), enoxaparin (5 μg/mL) and fondaparinux (5 μg/mL).
-
Phytomedicine
Deciphering the core antiviral mechanism of Yinqiao powder: Inhibition of dengue virus adsorption mediated by wogonin via host receptor HSP90AA1 blockade. [Abstract]2026 Jul:156:158184. PMID: 42061084 -
Mol Med
Targeting LINC02544/miR-497-5p/CAPRIN1 axis via exosome-based siRNA to overcome immunotherapy resistance in triple-negative breast cancer. [Abstract]2025 Aug 16;31(1):278. PMID: 40819077 -
Pharmaceutics
CC-90009, a Cereblon E3 Ligase Modulator, Exhibits Antiviral Efficacy Against JEV In Vitro and In Vivo via Targeted Degradation of GSPT1 and Viral NS5 Protein. [Abstract]2025 Nov 27;17(12):1524. PMID: 41471039 -
EMBO Rep
CDC42 supports HBV entry by NTCP translocation to the plasma membrane and macropinocytosis. [Abstract]2025 Sep 15. PMID: 40954218 -
-
iScience
Development of the FGFR4-ADC bearing the ferroptosis inducer sulfasalazine for hepatocellular carcinoma. [Abstract]2025 Oct 6;28(11):113718. PMID: 41210985 -
Tissue Cell
ATF5 inhibits autophagy and the Wnt/β-catenin pathway by upregulating mTOR to suppress the stemness of liver cancer stem cells. [Abstract]2025 Dec:97:103094. PMID: 40857870
Solvant et solubilité
H2O : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
Pureté et documentation
-
Fiche technique (284 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instruction de manipulation (2659 KB)
Références
[1]. Capila I, et al. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412. [Content Brief]
[2]. Ito M, et al. Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro. Antiviral Res. 1987 Jul;7(6):361-7. [Content Brief]
[3]. Ganapathy R, et al. Effect of heparin and fractionated heparin on trophoblast invasion. Hum Reprod. 2007 Sep;22(9):2523-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Heparin Related Classifications
HY-17567 Related Classifications
Powered by Bioz