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L-Tryptophan

(Synonyms: Tryptophan; Tryptophane)
16 Cited Publications
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Based on 16 publication(s) in Google Scholar

L-Tryptophan (Tryptophan) is an orally active and essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. L-Tryptophan can promote an increase in stemness and osteogenic ability of BMSCs in vitro and in vivo. L-Tryptophan inhibits cell proliferation and induced cell cycle arrest with high levels.

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  • Pureté: 99.99%
  • CAS No.: 73-22-3
  • Formule: C11H12N2O2
  • Masse moléculaire:204.23
  • Stockage:

    4°C, protect from light, stored under nitrogen

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

  • L-Tryptophan Chemical Structure
    L-Tryptophan Chemical Structure
  • Experimental Validation Results for L-Tryptophan
  • Experimental Validation Results for L-Tryptophan
  • Experimental Validation Results for L-Tryptophan
  • Experimental Validation Results for L-Tryptophan
  • Experimental Validation Results for L-Tryptophan
  • Experimental Validation Results for L-Tryptophan
CAS No.: 73-22-3
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Cell Proliferation/Viability AssayWBCell Migration/Invasion AssayHistological Imaging/StainingIHC
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  • L-Tryptophan Chemical Structure
    L-Tryptophan Chemical Structure
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    L-Tryptophan purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2024 Dec 19;10(1):154. [Abstract]

    Customer Validation
     L-Tryptophan promots TGF-β1-induced EMT. A: MLE-12 cell line was subjected to 12 h pretreatment with L-Tryptophan (5, 50, 500, and 1000 μM), prior to 24 or 48 h treatment with 10 ng/mL TGF-β1 for EMT induction. The viability of MLE-12 cells was detected using CCK-8 assay; B: MLE-12 cells were pretreated with 50 μM L-Tryptophan for 12 h, prior to 48 h treatment with 10 ng/mL TGF-β1 and then examined for B cell viability by CCK-8 assay. N = 3, *p < 0.05, **p < 0.01, vs. Control group; #p < 0.05, ##p < 0.01, vs. the TGF-β1 group.

  • 1/16

    L-Tryptophan purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2024 Dec 19;10(1):154. [Abstract]

    Customer Validation
     L-Tryptophan (50 μM, 12 h pretreatmen) promots TGF-β1-induced EMT. E-cadherin, α-SMA, Vimentin, and N-cadherin protein contents using Western blot. N = 3, *p < 0.05, **p < 0.01, vs. Control group; #p < 0.05, ##p < 0.01, vs. the TGF-β1 group.

  • 1/16

    L-Tryptophan purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2024 Dec 19;10(1):154. [Abstract]

    Customer Validation
     L-Tryptophan promots TGF-β1-induced fibroblast activation. WML2 cells were pretreated with 50 μM L-Tryptophan for 12 h, prior to 48 h treatment with 10 ng/mL TGF-β1 and then examined for the migratory ability using plate scratch assay. N = 3, *p < 0.05, **p < 0.01, vs. Control group; #p < 0.05, ##p < 0.01, vs. the TGF-β1 group.

  • 1/16

    L-Tryptophan purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2024 Dec 19;10(1):154. [Abstract]

    Customer Validation
     L-Tryptophan promots bleomycin (BLM)- and silica-induced pulmonary fibrosis (PF) in vivo. The PF mouse models were induced using BLM and silica, and then mice were treated with L-Tryptophan (50 mg/kg/day) on the second day for 4 weeks. The mice were randomly divided into five groups: Sham, BLM, Silica, BLM + Try, and Silica + Try groups. The pathological damages in mouse lung tissue samples were observed using HE staining.

  • 1/16

    L-Tryptophan purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2024 Dec 19;10(1):154. [Abstract]

    Customer Validation
     L-Tryptophan promots bleomycin (BLM)- and silica-induced pulmonary fibrosis (PF) in vivo. The PF mouse models were induced using BLM and silica, and then mice were treated with L-Tryptophan (50 mg/kg/day) on the second day for 4 weeks. Then, the mice were randomly divided into five groups: Sham, BLM, Silica, BLM + Try, and Silica + Try groups. α-SMA and E-cadherin levels within mouse pulmonary tissue samples were detected using IHC. n = 6. **p < 0.01, vs. the Sham mice, ##p < 0.01, vs. the BLM or Silica mice.

  • 1/16

    L-Tryptophan purchased from MedChemExpress. Usage Cited in: Obesity. 2023 May;31(5):1311-1325. [Abstract]

    Customer Validation
     L-Trp (0.7 mM; 48 h) enhances the PA (palmitic acid) increased expression of PDX-1, NKX6.1, and MAFA in MIN6 cells. whereas CLP-3094 (CLP; 0.7 μM; 48 h) causes an opposing effect.

  • L-Tryptophan