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SB-431542

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Based on 302 publication(s) in Google Scholar

SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways.

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  • Pureté: 99.85%
  • CAS No.: 301836-41-9
  • Formule: C22H16N4O3
  • Masse moléculaire:384.39
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • SB-431542 Chemical Structure
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • SB-431542 Chemical Structure
    SB-431542 Chemical Structure
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
  • Experimental Validation Results for SB-431542
CAS No.: 301836-41-9
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  • SB-431542 Chemical Structure
    SB-431542 Chemical Structure
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    SB-431542 purchased from MedChemExpress. Usage Cited in: Nat Genet. 2024 Feb;56(2):294-305. [Abstract]

    Customer Validation
     Trophoblast organoids constructed from hTSCs-BL. Trophoblast markers: CDH1 and hCG. Briefly, hTSCs were cultured in hTSCs medium (DMEM/F12 supplemented with 0.1 mM 2-mercaptoethanol, 0.2% FBS, 0.5% Penicillin–Streptomycin, 0.3% BSA, 1% ITS-X supplement, 1.5 μg/ml L-ascorbicacid, 50 ng/mL Epidermal Growth Factor (EGF)(MedChemExpress), 2 μM CHIR99021 (MedChemExpress), 0.5 μM A83-01 (MedChemExpress), 1 μM SB431542 (MedChemExpress), 0.8 mM Valproic acid and 5 μM Y27632 (MedChemExpress).

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: Nat Aging. 2024 Apr;4(4):568-583. [Abstract]

    Customer Validation
     Aβfibril-treated primary neurons from WT mice were preincubated with SB431542 (10 μM) or MK-2206 (10 μM) for 20 min followed by exposure to GDF1 (100 ng/mL) for 30 min. Imunoblotting was used to test the levels of Akt, p-Akt, AEP and APP N585

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 May:161:114537. [Abstract]

    Customer Validation
     SB431542 (4.2 mg/kg; i.p.; single daily for 3 days) reduces the expression of α-SMA, collagen-I and p-Smad3 in SiO2-induced fibrosis lungs of mice.

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: Stem Cells. 2019 Feb;37(2):190-201. [Abstract]

    Customer Validation
     Western blot images show Smad2/3 phosphorylation is lower than baseline in the sh-GPM6B cells and higher than baseline in the GPM6B-sgRNA cells. The phosphorylation of Smad2/3 in the sh-GPM6B TGF-β1 group is elevated by Alantolactone and the phosphorylation is reduced by treatment with SB431542.

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: Stem Cells. 2019 Feb;37(2):190-201. [Abstract]

    Customer Validation
     Western blot analyses show the repression of SMC specific markers in the sh-GPM6B TGF-β1 group are abolished by Alantolactone in the sh-GPM6B and the enrichment of SMC specific markers in the GPM6B-sgRNA cells is cancelled by treatment with SB431542.

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2019 Mar;19(3):2107-2114. [Abstract]

    Customer Validation
     Effects of the TGF‑β1 inhibitor SB (20 μM) on mechanical force‑induced COL‑1 and MMP‑1 mRNA expression.

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: Phytother Res. 2019 Jan;33(1):214-223. [Abstract]

    Customer Validation
     Western analysis of FN and α-SMA in cardiac fibroblasts or NIH3T3 with treatments of (+)‐isobicyclogermacrenal, spathulenol, oxymatrine (OMT), and SB431542 at indicated concentrations.

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2018 May 23;19(6). pii: E1556. [Abstract]

    Customer Validation
     E-cadherin, N-cadherin, Snail, and MMP-2 expression in HCC cells is examined by Western blot analysis. GAPDH is used as a loading control.

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: Mol Oncol. 2018 Mar;12(3):305-321. [Abstract]

    Customer Validation
     Western blot analysis of EGFR, total and phosphorylated Smad3, total and phosphorylated ERK protein expression in cell lysates from two breast cancer cells pretreated with SB431542 and then stimulated with TGF-β for the indicated times.

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2018 Sep;22(9):4354-4365. [Abstract]

    Customer Validation
     p-FOXO3a (Thr32), p-FOXO3a (Ser253), FOXO3a, p-Akt and Akt expression via western blot following treatment with PBS, ASV, TGF-b1, TGF-b1+ASV, TGF-b1+SB431542 or TGF-b1+LY294002.

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: Mol Cell Biochem. 2018 Feb;439(1-2):117-129. [Abstract]

    Customer Validation
     Protein expression levels of E-cadherin N-cadherin, p-ERK, ERK, TGF-β1, p-Smad2, and p-Smad3 in each group are analyzed by western blotting.

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: Brain Res Bull. 2018 May:139:38-47. [Abstract]

    Customer Validation
     pSmad2/3 protein levels are down-regulated by the ALK5 inhibitor SB431542 (rGDF11 group vs. rGDF11+SB group, p=0.000).

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: Immunol Lett. 2019 Feb:206:33-40. [Abstract]

    Customer Validation
     Monocytes were cultured with 20 ng/mL M-CSF with or without 10 ng/mL TGF-β1 for 2 days, with SB431542 (1 or 50 μM) or SIS3 (2.5 μM) having been added 30 min beforehand. Whole-cell lysates were subjected to SDS-PAGE and immunoblotted.

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: Oncol Lett. 2018 Mar;15(3):2801-2806. [Abstract]

    Customer Validation
     A549 cells are co cultured with 10.0 mM SB431542 for 48 h, the expression of TGF β1, Smad2 and caspase 3 are tested by western blot analysis and then analyzed.

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: Oncol Lett. 2018 Jun;15(6):9681-9686. [Abstract]

    Customer Validation
     A549 cells are treated with 1.0% CSE with or without 10.0 mM SB431542 for 48 h, the levels of TGF β1, p Smad2, and MMP3 is assayed by western blot analysis.

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2017 Apr 18;18(4). pii: E853. [Abstract]

    Customer Validation
     The protein level of Six2 and Ki67 after the treatment of phosphorylation Smad3 ( p-Smad3) inhibitor SB431542 (10 µM) for 48 h.

  • 1/16

    SB-431542 purchased from MedChemExpress. Usage Cited in: Oncol Lett. 2017 Jul;14(1):541-546. [Abstract]

    Customer Validation
     To investigate the effect of SB431542 on the accumulation of TGFβ1 and MMP3 in MM cells, RPMI 8226 cells are treated with 10, 100 and 1,000 nmol/mL SB431542 for 48 h. Western blotting is performed. The results demonstrate that SB431542 significantly decreases the accumulation of TGFβ1 and MMP3 at 100 and 1,000 nmol/mL when compared with the control. Smad2, as a signaling molecule, can be initially activated by TGFβ1. Therefore, the effect of SB431542 on the expression of Smad2 and p-Smad2 in RPM

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    SB-431542 purchased from MedChemExpress. Usage Cited in: Chin J Immun. 2016 (5): 615-619.

    Customer Validation
     10-1000 nM of SB431542 are co-cultured with RLE-6TN cells for 48 h. Expressions of p-Smad2 and Smad are detected by Western blot.

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    SB-431542 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2015 Sep;28(1):707-14. [Abstract]

    Customer Validation
     SB431542 is used to block the TGF-β1/Smad2 pathway and the expression of PLTP, p-Smad2 and cleaved caspase-3 is analyzed. (A) RLE-6TN cells are treated with 5–500 nM SB431542 for 72 h. Expression of PLTP and p-Smad2 is analyzed by Western blot. (B) CSE-treated rat lung epithelial cells are treated with 500 nM SB431542 to block the TGF-β1/Smad2 pathway.

  • SB-431542