A-176120
A-176120 is a selective inhibitor of farnesyl transferase (IC50=1.2 nM) based on a farnesyl pyrophosphate (FPP) analog, with superior selectivity against GGTaseI (IC50=423 nM), GGTaseII (IC50=3000 nM), and SSase (IC50>10 μM). A-176120 inhibits ras processing in H-ras transformed NIH3T3 cells and HCT116 K-ras mutant cells (ED50=1.6 and 0.5 μM, respectively). A-176120 has antiangiogenic and antitumor activities in vivo and reduces capillary structure formation and VEGF secretion.
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- CAS No.: 185049-54-1
- Formule: C33H29NO9
- Masse moléculaire:583.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
Chemical Information
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CAS No. 185049-54-1
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Masse moléculaire 583.58
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Formule C33H29NO9
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SMILES
O=C(C1=CC(C(N(CC2=CC=CC=C2OCC)CC3=CC=CC(OC4=CC=C(C)C=C4)=C3)=O)=C(C(O)=O)C=C1C(O)=O)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
A-176120 Related Classifications
HY-117807 Related Classifications
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