Antimalarial agent 8
Antimalarial agent 8 (Compound 7e) is a novel orally active class of antimalarials. Antimalarial agent 8 is potent in vitro against P. falciparum and is orally efficacious (40 mg/kg) in an in vivo mouse model of malaria.
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- CAS No.: 2715222-97-0
- Formule: C22H21Cl3N4O
- Masse moléculaire:463.79
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Plasmodium |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
32 μM
Compound: 7e.HCl
|
Cytotoxicity against human HEK293 cells by resazurin based cell viability assay
Cytotoxicity against human HEK293 cells by resazurin based cell viability assay
|
[PMID: 35300096] |
| Hepatocyte | CC50 |
8500 nM
Compound: 7e.HCl
|
Cytotoxicity against human hepatocytes measured after 96 hrs by DAPI staining based fluroscence assay
Cytotoxicity against human hepatocytes measured after 96 hrs by DAPI staining based fluroscence assay
|
[PMID: 35300096] |
Chemical Information
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CAS No. 2715222-97-0
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Masse moléculaire 463.79
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Formule C22H21Cl3N4O
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SMILES
O=C(C1=CC2=C(NC3=C2C=CC=C3C)C(C4=CC(Cl)=C(Cl)C=C4)=N1)NCCNC.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)