AZ13711265
AZ13711265 is an orally active PAK1 inhibitor with high selectivity. AZ13711265 has IC50 values of 0.58 nM and 0.11 µM for PAK1 and pPAK1, respectively. AZ13711265 has low lipophilicity and low clearance, and can be used as an in vivo probe compound for PAK1. AZ13711265 can be used in the study of cancer.
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- CAS No.: 2016806-55-4
- Formule: C28H35FN6O3S
- Masse moléculaire:554.68
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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PAK1 0.58 nM (IC50) |
pPAK1 0.11 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF-10A | IC50 |
0.11 μM
Compound: 14
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Inhibition of PAK1 phosphorylation in human MCF10A cells
Inhibition of PAK1 phosphorylation in human MCF10A cells
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[PMID: 27994749] |
Chemical Information
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CAS No. 2016806-55-4
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Masse moléculaire 554.68
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Formule C28H35FN6O3S
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SMILES
OCC1=CC(N(C2=NC(NC3=CC=C(N4[C@](C5)([H])CN(C)[C@]5([H])C4)C(S(=O)(CC)=O)=C3)=NC=C2F)C)=C(C)C=C1C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AZ13711265 Related Classifications
HY-119216 Related Classifications
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