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BMS-986156

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BMS-986156 is a fully humanized IgG1 agonist monoclonal antibody agonist corticosteroid-induced tumor necrosis factor receptor-related protein (GITR). BMS-986156 binds to GITR and promotes activation of T effector cells and inactivates T regulatory cells. BMS-986156 is indicated for use in advanced solid tumor studies.

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  • Pureté: 97.11%
  • Masse moléculaire:145.97 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for BMS-986156
  • Experimental Validation Results for BMS-986156
  • BMS-986156 Chemical Structure
    BMS-986156 Chemical Structure
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BMS-986156 Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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  • 1/16

    Flow cytometric analysis of 1X106 Jurkat cells with BMS-986156 (HY-P991178, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized Human GITR/TNFRSF18 Protein, His Tag can bind BMS-986156. The EC50 for this effect is 97.21 ng/mL.

  • BMS-986156 Chemical Structure
    1/16
  • BMS-986156
  • Flow cytometric analysis of 1X106 Jurkat cells with BMS-986156 (HY-P991178, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized Human GITR/TNFRSF18 Protein, His Tag can bind BMS-986156. The EC50 for this effect is 97.21 ng/mL.