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Cat. No.: HY-N19702

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Calphostin B

Calphostin B is a protein kinase C (PKC) inhibitor with an IC₅₀ of 1.04 μM in rats and an IC₅₀ of 22.9 μM for bovine cyclic adenosine monophosphate-dependent protein kinase (PKA). Calphostin B bears aromatic structures at positions C-14 and C-17, which accounts for its higher selectivity for PKC over PKA. Calphostin B can be used in studies related to human cervical cancer and human breast cancer.

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CAS No.: 124824-06-2
Formule: C₃₇H₃₄O₁₁
Masse moléculaire:654.66

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Please store the product under the recommended conditions in the Certificate of Analysis.

Calphostin B Chemical Structure

CAS No.: 124824-06-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

PKC

1.04 μM (IC₅₀)

PKA

22.9 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform PKC :

Voir tous les produits spécifiques à Isoform PKA :

In Vitro

Calphostin B inhibits partially purified rat brain PKC with an IC₅₀ of 1.04 μM and partially purified bovine heart PKA with an IC₅₀ of 22.9 μM^[1].
Calphostin B (1 h) inhibits the growth of human cervical cancer HeLa S₃ cells with an IC₅₀ of 2.56 μM and human breast cancer MCF-7 cells with an IC₅₀ of 1.61 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 124824-06-2
Masse moléculaire 654.66
Formule C₃₇H₃₄O₁₁
SMILES

O=C(C1=CC=CC=C1)OC(CC2=C(C(C3=C(C=C(C(C4=C5C6=C(O)C=C4OC)=C3C2=C5C(CC(C)O)=C(OC)C6=O)OC)O)=O)OC)C
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Cladosporium cladosporioides
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Kobayashi E, et al. Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1989 Oct;42(10):1470-4. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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Calphostin B

Voir tous les produits spécifiques à Isoform PKC

Voir tous les produits spécifiques à Isoform PKA