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Cat. No.: HY-151408

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CDK1-IN-4

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

CDK1-IN-4 (10d) is a selective CDK1 inhibitor with IC₅₀s of 44.52, 624.93 and 135.22 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN4 inhibits the growth of cancer cells by affecting cell cycle. CDK1-IN-4 can be used for the research of cancer.

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CAS No.: 3032997-16-0
Formule: C₂₆H₂₄ClN₅S
Masse moléculaire:474.02

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CDK1-IN-4 Chemical Structure

CAS No.: 3032997-16-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

CDK1

44.52 nM (IC₅₀)

CDK2

621.93 nM (IC₅₀)

CDK5

135.22 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform CDK :

In Vitro

CDK1-IN-4 (0-10 μM; 24 h) inhibits the growth of PDAC, melanoma, leukemia, colon and breast cancer cells^[1].
CDK1-IN-4 (0-1 μM) inhibits CDK1, CDK2 and CDK5 with IC₅₀s of 36.8, 305.17 and 369.37 nM, respectively^[1].
CDK1-IN-4 (0-10 μM) inhibits AXL, PTK2B, FGFR, JAK1, IGF1R and BRAF kinases with IC₅₀s of 2488, 8957, 7620, 8541, 4294 and 1156 nM, respectively^[1].
CDK1-IN-4 (0.88 μM; 24 h) decreases CDK1 protein level in vitro and affects cell cycle^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

PDAC, melanoma, leukemia, colon and breast cancer cell lines
Concentration:

0-10 μM
Incubation Time:

24 hours
Result:

Inhibited cell growth of PDAC, melanoma, leukemia, colon, and breast cancer cell over 69%, and inhibited MDA-PATC53 and PL45 cells with IC₅₀s of 0.88 and 1.14 μM, respectively.

Western Blot Analysis^[1]

Cell Line:

MDA-PATC53 cell line
Concentration:

0.88 μM
Incubation Time:

24 hours
Result:

Downregulated CDK1 protein level compared to untreated cells.

Cell Cycle Analysis^[1]

Cell Line:

MDA-PATC53 cell line
Concentration:

0.88 μM
Incubation Time:

24 hours
Result:

Significantly arrested in G2/M phase of the cell cycle compared with the untreated cells.

Chemical Information

CAS No. 3032997-16-0
Masse moléculaire 474.02
Formule C₂₆H₂₄ClN₅S
SMILES

S=C(N1CCN(C2=NN=C(CC3=CC=CC=C3)C4=C2C=CC=C4)CC1)NC5=CC=CC(Cl)=C5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

J Exp Clin Cancer Res

Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis. [Abstract]

2023 Sep 4;42(1):228. PMID: 37667382

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Akl L, et al. Identification of novel piperazine-tethered phthalazines as selective CDK1 inhibitors endowed with in vitro anticancer activity toward the pancreatic cancer. Eur J Med Chem. 2022 Aug 31;243:114704. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

CDK1-IN-4

1 Cited Publications

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- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
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CDK1-IN-4

Publications Citing Use of MedChemExpress (MCE) CDK1-IN-4

Voir tous les produits spécifiques à Isoform CDK

Activité biologique

Chemical Information

Publications (1)

Pureté et documentation

Références

Calculators

Help & FAQs

CDK1-IN-4 Related Classifications

HY-151408 Related Classifications