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Cendakimab

(Synonyms: RPC 4046; ABT 308; CC-93538)
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Cendakimab (RPC4046; ABT 308; CC-93538) is a selective, humanized, recombinant monoclonal antibody against the IL-13 molecule. Cendakimab has a high affinity and potency for both human wild-type and variant IL-13 and blocks binding of IL-13 to both IL-13Rα1 and IL-13Rα2 with IC50s of 352 pM and 631 pM by ELISA, respectively. Cendakimab recognizes both wild-type human IL-13 and the common polymorphic variant R110Q, with binding affinities of 52 and 50 pM, respectively. Cendakimab has the potential for IL-13-related allergic/inflammatory diseases (e.g., asthma and eosinophilic esophagitis).

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  • Pureté : 99.96%
  • CAS No.: 2151032-62-9
  • Masse moléculaire:146.44 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Cendakimab
  • Experimental Validation Results for Cendakimab
  • Cendakimab Chemical Structure
    Cendakimab Chemical Structure
CAS No.: 2151032-62-9
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Human IL-13 Protein can bind Cendakimab. The EC50 for this effect is 21.70 ng/mL.

  • Cendakimab Chemical Structure
    1/16
  • Cendakimab
  • Immobilized Human IL-13 Protein can bind Cendakimab. The EC50 for this effect is 21.70 ng/mL.