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Cat. No.: HY-164413

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CLM3

CLM3, a pyrazolopyrimidine derivative, is a multiple tyrosine kinase inhibitor. CLM3 shows antiproliferative and proapoptotic activity on endothelial and cancer cells, synergistically enhanced by SN38 (HY-13704). These effects are mainly due to its inhibition of phosphorylation of VEGFR-2, EGFR and RET tyrosine kinases and their related signaling pathways.

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CAS No.: 1312024-59-1
Formule: C₂₁H₂₁N₅
Masse moléculaire:343.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CLM3 Chemical Structure

CAS No.: 1312024-59-1

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
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Activité biologique

Description

IC₅₀ & Target

VEGFR2

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Cellular Effect

Cell Line	Type	Value	Description	References
8305C	IC₅₀	9.2 μM Compound: CLM3	Antiproliferative activity against human 8305C cells expressing RET after 72 hrs Antiproliferative activity against human 8305C cells expressing RET after 72 hrs	[PMID: 24447248]
TT	IC₅₀	26.93 μM Compound: CLM3	Antiproliferative activity against human TT cells Antiproliferative activity against human TT cells	[PMID: 24447248]

In Vitro

CLM3 (0-100 μM, 72 h) significantly decreases phospho-VEGFR-2, phospho-EGFR and phospho-RET levels in activated endothelial and cancer cells^[1].
CLM3 (0-100 μM, 72 h) greatly inhibits the expression of the cyclin D1 gene in endothelial and cancer cells, decreasing the cyclin D1 protein intracellular concentration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1312024-59-1
Masse moléculaire 343.42
Formule C₂₁H₂₁N₅
SMILES

C[C@@H](NC1=C2C(N(CCC3=CC=CC=C3)N=C2)=NC=N1)C4=CC=CC=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Bocci G, et al. Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells. Biochem Pharmacol. 2011 Jun 1;81(11):1309-16. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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CLM3

Voir tous les produits spécifiques à Isoform VEGFR

Voir tous les produits spécifiques à Isoform EGFR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CLM3 Related Classifications

HY-164413 Related Classifications