cRIPGBM chloride
Based on 1 Customer Validation
cRIPGBM chloride, an orally active, proapoptotic derivative. cRIPGBM can be generated from glioblastoma multiforme (GBM) cancer stem cells (CSCs). cRIPGBM(chloride) targets to receptor-interacting protein kinase 2 (RIPK2) to induce caspase 1-dependent apoptosis. cRIPGBM(chloride) suppresses the formation of RIPK2/TAK1 (prosurvival complex), and increases the formation of RIPK2/caspase 1 (proapoptotic complex). cRIPGBM(chloride) exerts potent anti-tumor activity in vivo in animal models.
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- Pureté: 99.82%
- CAS No.: 2361988-77-2
- Formule: C26H20ClFN2O2
- Masse moléculaire:446.90
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Caspase-1 |
RIPK2 |
cRIPGBM chloride (0.25 μM; 0-24 h) time-dependently activates caspase 1, caspase 9, and caspase 7, as well as PARP cleavage, in CBM-1 GBM CSCs[1].
cRIPGBM chloride (0.125 μM, 0.25 μM; 24 h) induces cell apoptosis mediated by caspase 1 in CBM-1 GBM CSCs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:GBM-1 GBM CSCs
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Concentration:50 nM, 100 nM, 125 nM, 250 nM, and 500 nM
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Incubation Time:3 h, 6 h, 12 h, and 24 h
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Result:Had the ability to regulate RIPK2 to act as a prosurvival or proapoptotic molecule. Significantly reduced RIPK2 binding to cIAP2 in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Orthotopic intracranial xenograft model in mouse[1]
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Dosage:50 mg/kg
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Administration:PO; twice daily, 8 h apart, starting at day 7 postinjection; last for 5 weeks
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Result:Monitored by Fluorescence Tomography System. Decreased the tumor signal, as well as tumor size.
Chemical Information
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CAS No. 2361988-77-2
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Appearance Solid
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Masse moléculaire 446.90
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Formule C26H20ClFN2O2
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Color Light yellow to yellow
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SMILES
O=C(C1=C2[N+](CC3=CC=C(F)C=C3)=C(C)N1CC4=CC=CC=C4)C5=C(C=CC=C5)C2=O.[Cl-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 25 mg/mL (55.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (278 KB)
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SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Korean - KR (761 KB)
- Portuguese - PT (761 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2376 mL | 11.1882 mL | 22.3764 mL | 55.9409 mL |
| 5 mM | 0.4475 mL | 2.2376 mL | 4.4753 mL | 11.1882 mL | |
| 10 mM | 0.2238 mL | 1.1188 mL | 2.2376 mL | 5.5941 mL | |
| 15 mM | 0.1492 mL | 0.7459 mL | 1.4918 mL | 3.7294 mL | |
| 20 mM | 0.1119 mL | 0.5594 mL | 1.1188 mL | 2.7970 mL | |
| 25 mM | 0.0895 mL | 0.4475 mL | 0.8951 mL | 2.2376 mL | |
| 30 mM | 0.0746 mL | 0.3729 mL | 0.7459 mL | 1.8647 mL | |
| 40 mM | 0.0559 mL | 0.2797 mL | 0.5594 mL | 1.3985 mL | |
| 50 mM | 0.0448 mL | 0.2238 mL | 0.4475 mL | 1.1188 mL |
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