CZL-077
CZL-077 is a potent, selective, and orally active p300/CBP bromodomain (BRD) inhibitor (p300 IC50 = 0.034 μM, CBP IC50 = 0.052 μM) exhibiting high selectivity over the BRDs of BET proteins (BRD2/3/4). CZL-077 inhibits cell growth with IC50 values of 0.024 μM and 5.6 μM in OPM-2 and 22RV1 cells, respectively. CZL-077 shows antitumor efficacy in OPM-2 and 22RV1 xenograft mouse models. CZL-077 can be used for multiple myeloma and prostate cancer research.
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- CAS No.: 3032444-06-4
- Formule: C30H26F3N5O2S
- Masse moléculaire:577.62
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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BRD2 (BD1) 3.81 μM (IC50) |
BRD2 (BD2) >10 μM (IC50) |
BRD3 (BD1) 5.54 μM (IC50) |
BRD3 (BD2) >10 μM (IC50) |
BRD4 BD1 6.45 μM (IC50) |
BRD4 BD2 >10 μM (IC50) |
p300 0.034 μM (IC50) |
CBP 0.052 μM (IC50) |
Chemical Information
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CAS No. 3032444-06-4
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Masse moléculaire 577.62
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Formule C30H26F3N5O2S
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SMILES
CC1=NC(CC2)=C(S1)C[C@@H]2N3C([C@H]4N(C5=CC=C(F)C(F)=C5)C([C@@H](F)C4)=O)=NC6=CC(C7=C(C)ON=C7C)=CC=C63
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CZL-077 Related Classifications
HY-180804 Related Classifications
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