ELQ-598
ELQ-598, as a prodrug, is converted into the active drug ELQ-596 upon oral administration. ELQ-598 demonstrates potent parasitic growth inhibition capabilities (IC50= 37 nM). ELQ-598 also shows low toxicity towards human cells (IC50= 19 μM). ELQ-598 can be used for research into babesiosis.
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- CAS No.: 3023709-99-8
- Formule: C28H23ClF3NO6
- Masse moléculaire:561.93
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Activité biologique
Description
In Vivo
ELQ-598 (10 mg/kg; p.o.; daily DPI 3-7) is effective at eliminating B. microti infection in mice[1].
ELQ-598 (10 mg/kg; p.o.; daily DPI 3-7) combined with atovaquone (HY-13832) can eliminative of the infection in the C3H/HeJ mice infected with B. duncani and SCID mice model infected with B. microti[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C3H mice genetically prone to B. duncani infection[1]
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Dosage:10mg/kg
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Administration:p.o.; daily DPI 3-7
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Result:Resulted in a complete elimination of the parasites. Mice survived for the duration of the study with no recurrence of parasitemia observed.
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Animal Model:C3H/HeJ mice for B. duncani infection, and SCID mice for B. microti infection[1]
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Dosage:10mg/kg with 10mg/kg atovaquone,
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Administration:p.o.; daily DPI 3-7
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Result:All mice survived without any recurrence of parasitemia.
A potent synergistic or additive effect of the drug combination in eradicating the lethal infection.This combination strategy offers enhanced efficacy compared to the use of either compound alone.
Chemical Information
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CAS No. 3023709-99-8
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Masse moléculaire 561.93
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Formule C28H23ClF3NO6
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SMILES
ClC1=CC2=C(N=C(C)C(C3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C3)=C2OCOC(OCC)=O)C=C1OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ELQ-598 Related Classifications
HY-163483 Related Classifications
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