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Eluvixtamab

(Synonyms: AMG-330)
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Eluvixtamab (AMG-330) is a bispecific T-cell engager (BiTE) antibody targeting CD33 and CD3, with a Kd of 5.1 nM and 8 nM for human and cynomolgus monkey CD3, respectively, and a Kd of 8 nM and 8.6 nM for human and cynomolgus monkey CD33, respectively. Eluvixtamab links T cells to CD33-expressing acute myeloid leukemia (AML) cells, triggers T-cell activation, and induces inflammatory adaptive immune escape characterized by PD-L1 upregulation in AML cells. Eluvixtamab is applicable to research related to acute myeloid leukemia.

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  • Pureté: 97.28%
  • CAS No.: 1679391-73-1
  • Masse moléculaire:54.34 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Eluvixtamab
  • Experimental Validation Results for Eluvixtamab
  • Experimental Validation Results for Eluvixtamab
  • Experimental Validation Results for Eluvixtamab
  • Eluvixtamab Chemical Structure
    Eluvixtamab Chemical Structure
CAS No.: 1679391-73-1
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Eluvixtamab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    (scFv-heavy-kappa)-(scFv-heavy-lambda)

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Eluvixtamab (HY-P99910). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Flow cytometric analysis of 1X106 THP-1 cells labeling CD33 with Eluvixtamab (HY-P99910, red). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Loaded Eluvixtamab on NTA biosensor, can bind Siglec-3/CD33 Protein, Human (HEK293, HY-P73643) with an affinity constant of 6.543E-10 M as determined in BLI assay.

  • Eluvixtamab Chemical Structure
    1/16
  • Eluvixtamab
  • Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Eluvixtamab (HY-P99910). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Flow cytometric analysis of 1X106 THP-1 cells labeling CD33 with Eluvixtamab (HY-P99910, red). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Loaded Eluvixtamab on NTA biosensor, can bind Siglec-3/CD33 Protein, Human (HEK293, HY-P73643) with an affinity constant of 6.543E-10 M as determined in BLI assay.
  • (scFv-heavy-kappa)-(scFv-heavy-lambda)