Erythrodiol
Based on 1 publication(s) in Google Scholar
Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis.
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- Pureté: 99.75%
- CAS No.: 545-48-2
- Formule: C30H50O2
- Masse moléculaire:442.72
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Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) Erythrodiol
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Activité biologique
ABCA1 protein[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | ED50 |
>50 μM
Compound: 16
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Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
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[PMID: 12027734] |
| B16 | IC50 |
33.4 μM
Compound: 16
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Growth inhibition of mouse B16 2F2 cells after 3 days
Growth inhibition of mouse B16 2F2 cells after 3 days
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[PMID: 12027734] |
| BMDC | IC50 |
>50 μM
Compound: 21
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Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL12 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL12 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
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[PMID: 23484668] |
| BMDC | IC50 |
>50 μM
Compound: 21
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Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated TNF-alpha production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated TNF-alpha production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
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[PMID: 23484668] |
| BMDC | IC50 |
13.51 μM
Compound: 21
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Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL-12p40 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL-12p40 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA
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[PMID: 23484668] |
| HEK293 | IC50 |
613 μM
Compound: 8
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Cytotoxicity against human HEK293 cells assessed as cell viability after 24 hrs by cell titer-blue assay
Cytotoxicity against human HEK293 cells assessed as cell viability after 24 hrs by cell titer-blue assay
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[PMID: 26473275] |
| HT-29 | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
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[PMID: 30057155] |
| HT-29 | IC50 |
>10 μM
Compound: 11
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Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay
Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay
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[PMID: 30057155] |
| J774 | IC50 |
50.3 μM
Compound: 5
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Cytotoxicity against mouse J774 cells by alamar blue assay
Cytotoxicity against mouse J774 cells by alamar blue assay
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[PMID: 17637068] |
| KB | IC50 |
7 μg/mL
Compound: erythrodiol
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Cytotoxicity against vincristine-sensitive human KB cells after 72 hrs by alamar blue assay
Cytotoxicity against vincristine-sensitive human KB cells after 72 hrs by alamar blue assay
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[PMID: 15043435] |
| MDA-MB-231 | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
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[PMID: 30057155] |
| MDA-MB-435 | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
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[PMID: 30057155] |
| OVCAR-3 | IC50 |
>10 μM
Compound: 11
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Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
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[PMID: 30057155] |
Erythrodiol (1-15 μM; 24 hours) enhances ABCA1 protein level in a concentration-dependent manner, and reachs significance at 10 and 15 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP-1 macrophage cells
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Concentration:1 μM, 2.5 μM, 5 μM, 10 μM, and 15 μM
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Incubation Time:24 hours
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Result:Increased ABCA1 protein expression.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 545-48-2
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Appearance Solid
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Masse moléculaire 442.72
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Formule C30H50O2
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Color White to off-white
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SMILES
C[C@@]12C([C@@]3([H])[C@](CO)(CCC(C)(C)C3)CC2)=CC[C@@]4([H])[C@]1(CC[C@]5([H])[C@@]4(CC[C@H](O)C5(C)C)C)C
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Structure Classification
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cancer Biother Radiopharm
Danggui Buxue Decoction Combined with Borneol Improves Cyclophosphamide-Induced Myelosuppression by Inhibiting CDK2. [Abstract]2025 Jun 16. PMID: 40523231
Solvant et solubilité
DMSO : 20 mg/mL (45.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2 mg/mL (4.52 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2588 mL | 11.2938 mL | 22.5876 mL | 56.4691 mL |
| 5 mM | 0.4518 mL | 2.2588 mL | 4.5175 mL | 11.2938 mL | |
| 10 mM | 0.2259 mL | 1.1294 mL | 2.2588 mL | 5.6469 mL | |
| 15 mM | 0.1506 mL | 0.7529 mL | 1.5058 mL | 3.7646 mL | |
| 20 mM | 0.1129 mL | 0.5647 mL | 1.1294 mL | 2.8235 mL | |
| 25 mM | 0.0904 mL | 0.4518 mL | 0.9035 mL | 2.2588 mL | |
| 30 mM | 0.0753 mL | 0.3765 mL | 0.7529 mL | 1.8823 mL | |
| 40 mM | 0.0565 mL | 0.2823 mL | 0.5647 mL | 1.4117 mL |
Erythrodiol Related Classifications
HY-N2419 Related Classifications
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