OSBP - oxysterol binding protein Gene

Also Known as OSBP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5007

About OSBP

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:59,574,398-59,615,774 (from NCBI)

This gene has 3 transcripts (splice variants), 255 orthologues and 11 paralogues. Ubiquitous expression in adrenal (RPKM 22.9), kidney (RPKM 22.7) and 25 other tissues.

Summary

Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]

OSBP Products (1)

mRNA	Protein	Name
NM_002556.3	NP_002547.1	oxysterol-binding protein 1

OSBP Protein Structure

PH

Oxysterol_BP

0
200
400
600
807 a.a.

Protein Preferred Names	Protein Names
oxysterol-binding protein 1

OSBP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	OSBP	P22059	VAPA	Homo sapiens	Q9P0L0	BiFC	25681634
Intra	OSBP	P22059	VAPA	Homo sapiens	Q9P0L0	Anti Tag CoIP	35271311
Intra	OSBP	P22059	VAPA	Homo sapiens	Q9P0L0	Lumier	32814053
Intra	OSBP	P22059	VAPA	Homo sapiens	Q9P0L0	BRET	29997244
Cross	OSBP	P22059	sseL	Salmonella typhimurium	Q8ZNG2	Anti Bait CoIP	21988961
Cross	OSBP	P22059	sseL	Salmonella typhimurium	Q8ZNG2	Anti Tag CoIP	21988961
Intra	OSBP	P22059	FKBP6	Homo sapiens	O75344	Lumier	25036637

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Deafness, Autosomal Dominant 67	DFNA67 Autosomal Dominant Nonsyndromic Deafness 67 Autosomal Dominant Deafness 67 Deafness, Autosomal Dominant, 67 Deafness, Autosomal Dominant, Type 67
Nonparalytic Poliomyelitis	Acute Nonparalytic Poliomyelitis Non-Paralytic Aseptic Meningitis
Amyotrophic Lateral Sclerosis 8	Amyotrophic Lateral Sclerosis Type 8 ALS8 Sclerosis, Lateral, Amyotrophic, Type Type 8
Acute Flaccid Myelitis
Acute Hemorrhagic Conjunctivitis	Viral Conjunctivitis Conjunctivitis, Acute Hemorrhagic Apollo Disease Epidemic Hemorrhagic Conjunctivitis Viral Conjunctiva Disorder Viral Conjunctivitis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-17514	Itraconazole		99.59%	Yes

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-101213	OSW-1	Antagonist	99.66%	Unkown
HY-17514S1	Itraconazole-d3		99.62%	Unkown
HY-124806	TTP-8307	Inhibitor	99.90%	Unkown
HY-17514S2	Itraconazole-d9		97.86%	Unkown
HY-148391	23-Oxa-OSW-1	Inhibitor	/	Unkown
HY-156275	OSBP-IN-1		/	Unkown
HY-178034	PROTAC OSBP Degrader-1	Degrader	/	Unkown
HY-178035	OSBP ligand-1	Inhibitor	/	Unkown
HY-178046	OSBP ligand-Linker Conjugate 1	Inhibitor	/	Unkown
HY-RS09835	OSBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09836	OSBP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-163891	Antifungal agent 107	Inhibitor	/	Unkown
HY-RS19928	Osbp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26430	Osbp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	OSBP	VGNC	VGNC:32456
Canis familiaris	OSBP	VGNC	VGNC:44149
Rattus norvegicus	OSBP	RGD	RGD:1308069
Felis catus	OSBP	VGNC	VGNC:68656
Mus musculus	OSBP	MGD	MGI:97447
Macaca mulatta	OSBP	VGNC	VGNC:75718
Others	OSBP	NCBI