Hydroxyrubicin
Hydroxyrubicin is an antitumor agent. Hydroxyrubicin can induce topoisomerase II-mediated DNA cleavage. Hydroxyrubicin induces DNA unwinding. Hydroxyrubicin has a significant inhibitory effect on tumor cells. Hydroxyrubicin can be used for the study of Multidrug-resistant (MDR) leukemia.
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- CAS No.: 73113-90-3
- Formule: C27H28O12
- Masse moléculaire:544.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
0.856 μM
Compound: 11
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Cytotoxicity against human K562 cells incubated for 2 hrs by cell titre blue viability assay
Cytotoxicity against human K562 cells incubated for 2 hrs by cell titre blue viability assay
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[PMID: 37561481] |
| MEL-JUSO | IC50 |
1.904 μM
Compound: 11
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Cytotoxicity against human MEL-JUSO cells incubated for 2 hrs by cell titre blue viability assay
Cytotoxicity against human MEL-JUSO cells incubated for 2 hrs by cell titre blue viability assay
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[PMID: 37561481] |
| U2OS | IC50 |
6.793 μM
Compound: 11
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Cytotoxicity against human U2OS cells incubated for 2 hrs by cell titre blue viability assay
Cytotoxicity against human U2OS cells incubated for 2 hrs by cell titre blue viability assay
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[PMID: 37561481] |
In Vitro
Hydroxyrubicin (1-10 μM, 30 min) induces topoisomerase II-mediated DNA cleavage in human c-myc-origin DNA[1].
Hydroxyrubicin (2.5-10 μM, 30 min) induces concentration-dependent DNA unwinding[1].
Hydroxyrubicin (1 h) appears to be slightly more cytotoxic than Doxorubicin (HY-15142A) in the sensitive KB3.1 cell line (IC50: 0.35 μM and 0.8 μM) and is 20-fold more cytotoxic on KB-V1 cells than doxorubicin (IC50: 2 μM and 40 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Healthy ICR Swiss mice[2].
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Dosage:79.1 mg/kg
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Administration:I.v., once
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Result:Showed significant reduction in granulocytes.
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Animal Model:Chronic cardiotoxicity was induced in healthy ICR Swiss mice through repeated administration[2].
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Dosage:12 mg/kg
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Administration:I.v., once weekly for 11 weeks
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Result:Mild lesions were observed in 5 out of 10 mice.
The degree of myocardial fibrosis was relatively mild.
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Animal Model:The model was established using male BDF1 mice (weighing 18-22 g) by intraperitoneal injection of 1×106 P388/Dox leukemia cells (drug-resistant strain)[2].
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Dosage:25 mg/kg, 37.5 mg/kg, 50.0 mg/kg
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Administration:I.v., once
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Result:Showed activity in the range of 25-50 mg/kg and no toxicity or death.
Chemical Information
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CAS No. 73113-90-3
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Masse moléculaire 544.50
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Formule C27H28O12
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SMILES
OC1=C2C([C@H](C[C@@](C(CO)=O)(O)C2)O[C@@]3([H])C[C@@H]([C@H](O)[C@H](C)O3)O)=C(O)C4=C1C(C5=CC=CC(OC)=C5C4=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hydroxyrubicin Related Classifications
HY-105510 Related Classifications
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