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Cat. No.: HY-134199

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IMP-1002

IMP-1002 is a Plasmodium N-myristoyltransferase (NMT) inhibitor. IMP-1002 inhibits myristoylation activity, blocks parasite development. IMP-1002 can be used for the research of malaria.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2059148-58-0
Formule: C₂₅H₃₀FN₅O
Masse moléculaire:435.55

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IMP-1002 Chemical Structure

CAS No.: 2059148-58-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

IMP-1002 is a Plasmodium N-myristoyltransferase (NMT) inhibitor. IMP-1002 inhibits myristoylation activity, blocks parasite development. IMP-1002 can be used for the research of malaria^[1].

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In Vitro

IMP-1002 (0.54-400 nM; 96 h) potently inhibits the growth of P. falciparum 3D7 erythrocytic stage parasites with an EC₅₀ of 34 ± 5.8 nM following 96 h of treatment^[1].
IMP-1002 (140 nM) inhibits protein myristoylation in P. falciparum 3D7 WT parasites during the 36-45 h post-invasion window, but does not inhibit myristoylation in PfNMT^[G386E] clones^[1].
IMP-1002 (140 nM; 45 h) induces developmental arrest in P. falciparum 3D7 WT parasites during a 45 h post-invasion treatment period, but does not arrest development in PfNMT^[G386E] clones^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2059148-58-0
Masse moléculaire 435.55
Formule C₂₅H₃₀FN₅O
SMILES

FC=1C=CC(=C(OCCC=2C(=NN(C2C)C)C)C1)C3=CC=C4C(=C3)C(=NN4C)CN(C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Schlott AC, et al. Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors. Cell Chem Biol. 2019;26(7):991-1000.e7. [Content Brief]

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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