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Cat. No.: HY-W452285

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Isoplumbagin

Isoplumbagin is antimicrobial agent. Isoplumbagin exhibits anticancer activity mainly through modulating mitochondrial dynamics and function.

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CAS No.: 14777-17-4
Formule: C₁₁H₈O₃
Masse moléculaire:188.18

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Isoplumbagin Chemical Structure

CAS No.: 14777-17-4

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Isoplumbagin is antimicrobial agent. Isoplumbagin exhibits anticancer activity mainly through modulating mitochondrial dynamics and function^[1].

Voir tous les produits spécifiques à Isoform Antibiotic :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	GI₅₀	2.7 μM Compound: 2	Antiproliferative activity against human BT-549 cells measured after 72 hrs by SRB assay Antiproliferative activity against human BT-549 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
CAL-51	GI₅₀	2.5 μM Compound: 2	Antiproliferative activity against human CAL-51 cells measured after 72 hrs by SRB assay Antiproliferative activity against human CAL-51 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
HCC1954	GI₅₀	0.34 μM Compound: 2	Antiproliferative activity against human HCC1954 cells measured after 72 hrs by SRB assay Antiproliferative activity against human HCC1954 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
HCT-116	GI₅₀	0.46 μM Compound: 2	Antiproliferative activity against human HCT-116 cells measured after 72 hrs by SRB assay Antiproliferative activity against human HCT-116 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
K562	GI₅₀	1.3 μM Compound: 2	Antiproliferative activity against human K562 cells measured after 72 hrs by SRB assay Antiproliferative activity against human K562 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
MCF7	GI₅₀	1.4 μM Compound: 2	Antiproliferative activity against human MCF7 cells measured after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
MOLM-13	GI₅₀	4.1 μM Compound: 2	Antiproliferative activity against human MOLM-13 cells measured after 72 hrs by SRB assay Antiproliferative activity against human MOLM-13 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
MV4-11	GI₅₀	26.5 μM Compound: 2	Antiproliferative activity against human MV4-11 cells measured after 72 hrs by SRB assay Antiproliferative activity against human MV4-11 cells measured after 72 hrs by SRB assay	[PMID: 35687347]
NCI-H1299	IC₅₀	1.5 μM Compound: 143	Cytotoxicity against human NCI-H1299 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis Cytotoxicity against human NCI-H1299 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis	[PMID: 38458106]
PC-3	IC₅₀	6 μM Compound: 143	Cytotoxicity against human PC-3 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis Cytotoxicity against human PC-3 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis	[PMID: 38458106]
U-87MG ATCC	IC₅₀	2.4 μM Compound: 143	Cytotoxicity against human U87 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis Cytotoxicity against human U87 cells incubated for 48 hrs by MTT reagent based spectrophotometric analysis	[PMID: 38458106]

Chemical Information

CAS No. 14777-17-4
Masse moléculaire 188.18
Formule C₁₁H₈O₃
SMILES

O=C1C(C)=CC(C2=C1C(O)=CC=C2)=O
Structure Classification
- Others
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Signal Pathway Related

Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Tsao YC, et al. Discovery of Isoplumbagin as a Novel NQO1 Substrate and Anti-Cancer Quinone. Int J Mol Sci. 2020 Jun 19;21(12):4378. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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