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Cat. No.: HY-121849

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KL-1156

BMS-358233 (compound 3) is a Lck inhibitor (IC₅₀: 1 nM; Ki: 540 pM) and inhibits T cell proliferation (IC₅₀: 262 nM).

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CAS No.: 819868-62-7
Formule: C₁₇H₁₇NO₄
Masse moléculaire:299.32

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

KL-1156 Chemical Structure

CAS No.: 819868-62-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

BMS-358233 (compound 3) is a Lck inhibitor (IC₅₀: 1 nM; Ki: 540 pM) and inhibits T cell proliferation (IC₅₀: 262 nM).

IC₅₀ & Target

IC50: 1 nM (Lck)^[1]

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Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H23	GI₅₀	9.316 μM Compound: KL-1156	Cytotoxicity against human NCI-H23 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human NCI-H23 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 24792464]
NCI-H23	GI₅₀	9.316 μM Compound: KL-1156	Cytotoxicity against human NCI-H23 cells Cytotoxicity against human NCI-H23 cells	[PMID: 20579876]
RAW264.7	IC₅₀	37.2 μM Compound: KL-1156	Inhibition of NF-kappaB (unknown origin) transcriptional activity in LPS-induced mouse RAW264.7 cells after 1 hr by secreted alkaline phosphatase assay Inhibition of NF-kappaB (unknown origin) transcriptional activity in LPS-induced mouse RAW264.7 cells after 1 hr by secreted alkaline phosphatase assay	[PMID: 25953156]
RAW264.7	IC₅₀	40.1 μM Compound: KL-1156	Inhibition of transcriptional activity of NF-kappaB (unknown origin) transfected in LPS-stimulated mouse RAW264.7 cells after 16 hrs by secretory alkaline phosphatase reporter gene assay Inhibition of transcriptional activity of NF-kappaB (unknown origin) transfected in LPS-stimulated mouse RAW264.7 cells after 16 hrs by secretory alkaline phosphatase reporter gene assay	[PMID: 24792464]
RAW264.7	IC₅₀	40.1 μM Compound: KL-1156	Inhibition of LPS-induced NF-kappaB transcriptional activity in mouse RAW264.7 cells Inhibition of LPS-induced NF-kappaB transcriptional activity in mouse RAW264.7 cells	[PMID: 20579876]
RAW264.7	IC₅₀	53 μM Compound: KL-1156	Inhibition of LPS-induced NFkappaB (unknown origin) transcriptional activity expressed in mouse RAW264.7 cells incubated for 16 hrs by SEAP based reporter gene assay Inhibition of LPS-induced NFkappaB (unknown origin) transcriptional activity expressed in mouse RAW264.7 cells incubated for 16 hrs by SEAP based reporter gene assay	[PMID: 27096046]

Chemical Information

CAS No. 819868-62-7
Masse moléculaire 299.32
Formule C₁₇H₁₇NO₄
SMILES

O=C(NC1=CC=CC=C1)C2CCC3=C(C=C(C(O)=C3)OC)O2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Inhibitory mechanism of chroman compound on LPS-induced nitric oxide production and nuclear factor-jB activation

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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KL-1156

Voir tous les produits spécifiques à Isoform Src

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

KL-1156 Related Classifications

HY-121849 Related Classifications