country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-155785

Copy Link Print Information

MTP

MTP is a PKM2 inhibitor. MTP induces cancer cell apoptosis by modulating caspase-3 activation. MTP induces autophagy and increases ROS generation. MTP also inhibits JAK2 signaling. MTP can be used for research of oral squamous cell carcinoma.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2377372-62-6
Formule: C₂₉H₂₃F₃N₄O₂
Masse moléculaire:516.51

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

MTP Chemical Structure

CAS No.: 2377372-62-6

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- Essai clinique
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

JAK2

Voir tous les produits spécifiques à Isoform JAK :

Cellular Effect

Cell Line	Type	Value	Description	References
LNCaP	IC₅₀	>2 μM Compound: 1; Tr-87	Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
MCF7	IC₅₀	1 μM Compound: 1; Tr-87	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
MDA-MB-231	IC₅₀	0.1 μM Compound: 1; Tr-87	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H157	IC₅₀	>2 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H157	IC₅₀	>2 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H157 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H157 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H1650	IC₅₀	0.2 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H1650 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H1650 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H1975	IC₅₀	1 μM Compound: 1; Tr-87	Antiproliferative activity against human NCI-H1975 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
NCI-H460	IC₅₀	1.5 μM Compound: 1; Tr-87	Antiproliferative activity against human H460 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human H460 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
PC-3	IC₅₀	0.6 μM Compound: 1; Tr-87	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]
PC-9	IC₅₀	0.5 μM Compound: 1; Tr-87	Antiproliferative activity against human PC9 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human PC9 cells harboring EGFR mutant assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31465224]

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 2377372-62-6
Masse moléculaire 516.51
Formule C₂₉H₂₃F₃N₄O₂
SMILES

C#CC(NC1=CC=C(C=C1)N2N=C(C=C2C3=CC=C(C=C3)C4=CC=C(C=C4)C(F)(F)F)CCC(NC)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Weng JR, et al. A PKM2 inhibitor induces apoptosis and autophagy through JAK2 in human oral squamous cell carcinoma cells. Chem Biol Interact. 2023 Aug 1;380:110538. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- Essai clinique
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

MTP

Voir tous les produits spécifiques à Isoform JAK