OAT-2068
OAT-2068 is a selective, high activity and orally active inhibitor of mouse chitotriosidase (mCHIT1) (IC50=29 nM) and displays 143-fold selectivity over m AMCase (IC50=4170 nM). OAT-2068 displays a good pharmacokinetic profile and is an ideal tool to study the role of CHIT1 in biological systems, including animal models of human diseases.
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- CAS No.: 2221950-65-6
- Formule: C23H36ClN7
- Masse moléculaire:446.03
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
IC50: 29 nM (mCHIT1); 4200 nM (mAMCase)IC50: 67 nM (hCHIT1); 1300 nM (hAMCase)[2]
OAT-2068 is a potent inhibitor developed for mAMCase (IC50=4200 nM) and mCHIT1(IC50=29 nM), which also displays activity toward hAMCase (IC50=67 nM) and hCHIT1 (IC50=1300 nM), it exhibits off-target activity toward the human ether-a-go-go-related gene (hERG)(hERG IC50=2.4 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2221950-65-6
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Masse moléculaire 446.03
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Formule C23H36ClN7
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SMILES
NC1=NNC(N2CCC(N3[C@@H](CC4=CC=C(Cl)C=C4)CN(CC(C)C)[C@@H](C)C3)CC2)=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Marzena Mazur, et al. Discovery of selective, orally bioavailable inhibitor of mouse chitotriosidase. Bioorg Med Chem Lett. 2018 Feb 1;28(3):310-314. [Content Brief]
[2]. Gleb Andryianau, et al. Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase. ACS Med Chem Lett [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OAT-2068 Related Classifications
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