Oncrasin-72
Based on 1 Customer Validation
Oncrasin-72 (NSC-743380) is an RNA polymerase II inhibitor with activity in inhibiting growth and inducing cell death in human cancer cells. Oncrasin-72 exhibits antitumor activity through JNK activation and STAT3 inhibition. Analytical method development and validation for Oncrasin-72 is essential for quantifying its concentration in biological fluids for pharmacokinetic studies. This method was able to successfully quantify Oncrasin-72 in different dose groups when applied in rat plasma.
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- Pureté: 97.61%
- CAS No.: 92407-90-4
- Formule: C16H14ClNO
- Masse moléculaire:271.74
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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RNA Polymerase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H157 | IC50 |
<=0.2 μM
Compound: 34
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Antitumor activity against human NCI-H157 cells assessed as cell viability after 3 days by sulforhodamine B assay
Antitumor activity against human NCI-H157 cells assessed as cell viability after 3 days by sulforhodamine B assay
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[PMID: 21443218] |
| NCI-H460 | IC50 |
<=0.2 μM
Compound: 34
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Antitumor activity against human H460 cells assessed as cell viability after 3 days by sulforhodamine B assay
Antitumor activity against human H460 cells assessed as cell viability after 3 days by sulforhodamine B assay
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[PMID: 21443218] |
| NCI-H460 | IC50 |
0.019 μM
Compound: 34
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Cytotoxicity against human H460 cells assessed as cell viability after 3 days by sulforhodamine B assay
Cytotoxicity against human H460 cells assessed as cell viability after 3 days by sulforhodamine B assay
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[PMID: 21443218] |
Chemical Information
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CAS No. 92407-90-4
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Appearance Solid
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Masse moléculaire 271.74
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Formule C16H14ClNO
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Color White to off-white
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SMILES
ClC1=CC=CC(CN2C=C(CO)C3=C2C=CC=C3)=C1
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Synonyms
NSC-743380
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (368.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6800 mL | 18.3999 mL | 36.7999 mL | 91.9997 mL |
| 5 mM | 0.7360 mL | 3.6800 mL | 7.3600 mL | 18.3999 mL | |
| 10 mM | 0.3680 mL | 1.8400 mL | 3.6800 mL | 9.2000 mL | |
| 15 mM | 0.2453 mL | 1.2267 mL | 2.4533 mL | 6.1333 mL | |
| 20 mM | 0.1840 mL | 0.9200 mL | 1.8400 mL | 4.6000 mL | |
| 25 mM | 0.1472 mL | 0.7360 mL | 1.4720 mL | 3.6800 mL | |
| 30 mM | 0.1227 mL | 0.6133 mL | 1.2267 mL | 3.0667 mL | |
| 40 mM | 0.0920 mL | 0.4600 mL | 0.9200 mL | 2.3000 mL | |
| 50 mM | 0.0736 mL | 0.3680 mL | 0.7360 mL | 1.8400 mL | |
| 60 mM | 0.0613 mL | 0.3067 mL | 0.6133 mL | 1.5333 mL | |
| 80 mM | 0.0460 mL | 0.2300 mL | 0.4600 mL | 1.1500 mL | |
| 100 mM | 0.0368 mL | 0.1840 mL | 0.3680 mL | 0.9200 mL |
Oncrasin-72 Related Classifications
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