country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-157577

Copy Link Print Information

PROTAC(H-PGDS)-8

PROTAC (H-PGDS)-8 is an H-PGDS PROTAC inhibitor with a IC₅₀ of 0.14 μM. PROTAC (H-PGDS)-8 binds to H-PGDS and inhibits its enzymatic activity. PROTAC (H-PGDS)-8 inhibits the production of PGD₂ in cancer cells. PROTAC (H-PGDS)-8 can be used for the research of Duchenne muscular dystrophy.
(Pink: Target protein ligand; Blue: Cereblon ligand (HY-W460193); Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2761281-51-8
Formule: C₄₁H₄₀N₈O₇
Masse moléculaire:756.81

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

PROTAC(H-PGDS)-8 Chemical Structure

CAS No.: 2761281-51-8

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

PROTAC (H-PGDS)-8 is an H-PGDS PROTAC inhibitor with a IC₅₀ of 0.14 μM. PROTAC (H-PGDS)-8 binds to H-PGDS and inhibits its enzymatic activity. PROTAC (H-PGDS)-8 inhibits the production of PGD₂ in cancer cells. PROTAC (H-PGDS)-8 can be used for the research of Duchenne muscular dystrophy^[1]. (Pink: Target protein ligand; Blue: Cereblon ligand (HY-W460193); Black: linker).

IC₅₀ & Target^[1]

H-PGDS

0.14 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform Prostaglandin Receptor :

In Vitro

PROTAC(H-PGDS)-8 (0-10000 pM; 6 h) does not induce degradation of H-PGDS protein in KU812 cells at concentrations up to 10000 pM over 6 h^[1].
PROTAC(H-PGDS)-8 (2.44 nM-2.50 μM; 1 h) binds to recombinant human H-PGDS protein with an IC₅₀ of 0.14 μM^[1].
PROTAC(H-PGDS)-8 (100-3000 pM; 6 h) suppresses PGD₂ production in KU812 cells at concentrations ≥1000 pM after 6 h incubation, with less potent activity than PROTAC(H-PGDS)-7 (compound 6)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

KU812 cells
Concentration:

0, 10, 100, 1000, 10000 pM
Incubation Time:

6 h
Result:

Showed no reduction of H-PGDS protein levels across all tested concentrations and incubation time, with H-PGDS expression remaining at ~90-100% of the DMSO-treated control.

Chemical Information

CAS No. 2761281-51-8
Masse moléculaire 756.81
Formule C₄₁H₄₀N₈O₇
SMILES

O=C(C1CCN(CC1)C2=CC=C(C=C2)NC(C3=CN=C(N=C3)OC4=CC=CC=C4)=O)N5CCN(CC5)C6=C(C7=CC=C6)C(N(C7=O)C8CCC(N(C8=O)C)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Yokoo H, et al. Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design. Journal of medicinal chemistry. 2021 Nov 11;64(21):15868-15882. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

PROTAC(H-PGDS)-8

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform Prostaglandin Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PROTAC(H-PGDS)-8 Related Classifications

HY-157577 Related Classifications